Biological and Molecular Docking Evaluation of a Benzylisothiocyanate Semisynthetic Derivative From Moringa oleifera in a Pre-clinical Study of Temporomandibular Joint Pain

Biological and Molecular Docking Evaluation of a Benzylisothiocyanate Semisynthetic Derivative From Moringa oleifera in a Pre-clinical Study of Temporomandibular Joint Pain

ObjectiveMoringa oleifera possesses multiple biological effects and the 4-[(4′-O-acetyl-α-L- rhamnosyloxy) benzyl] isothiocyanate accounts for them. Based on the original isothiocyanate molecule we obtained a semisynthetic derivative, named 4-[(2′,3′,4′-O-triacetyl-α-L-rhamnosyloxy) N-benzyl] hydraz...

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Main Authors: Felipe Dantas Silveira, Francisco Isaac Fernandes Gomes, Danielle Rocha do Val, Hermany Capistrano Freitas, Ellen Lima de Assis, Diana Kelly Castro de Almeida, Helyson Lucas Bezerra Braz, Francisco Geraldo Barbosa, Jair Mafezoli, Marcos Reinaldo da Silva, Roberta Jeane Bezerra Jorge, Juliana Trindade Clemente-Napimoga, Deiziane Viana da Silva Costa, Gerly Anne de Castro Brito, Vicente de Paulo Teixeira Pinto, Gerardo Cristino-Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Neuroscience
Subjects:
Moringa oleifera
temporomandibular joint
nociception
formalin
opioid receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.742239/full

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