Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report
For children born with congenital heart defects (CHDs), extracorporeal life support may be necessary. This retrospective single-center study aimed to investigate the outcomes of children with CHDs on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors. Among the 88 patients,...
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MDPI AG
2023-07-01
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Online Access: | https://www.mdpi.com/2075-1729/13/7/1582 |
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author | Antonio Amodeo Milena Stojanovic Tugba Erdil Hitendu Dave Robert Cesnjevar Sebastian Paal Oliver Kretschmar Martin Schweiger |
author_facet | Antonio Amodeo Milena Stojanovic Tugba Erdil Hitendu Dave Robert Cesnjevar Sebastian Paal Oliver Kretschmar Martin Schweiger |
author_sort | Antonio Amodeo |
collection | DOAJ |
description | For children born with congenital heart defects (CHDs), extracorporeal life support may be necessary. This retrospective single-center study aimed to investigate the outcomes of children with CHDs on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors. Among the 88 patients, 36 (41%) had a single-ventricle heart defect, while 52 (59%) had a biventricular defect. In total, 25 (28%) survived, with 7 (8%) in the first group and 18 (20%) in the latter. A <i>p</i>-value of 0.19 indicated no significant difference in survival rates. Children with biventricular hearts had shorter ECMO durations but longer stays in the intensive care unit. The overall rate of complications on ECMO was higher in children with a single ventricle (odds ratio [OR] 1.57, 95% confidence interval [CI] 0.67–3.7); bleeding was the most common complication in both groups. The occurrence of a second ECMO run was more frequent in patients with a single ventricle (22% vs. 9.6%). ECMO can be effective for children with congenital heart defects, including single-ventricle patients. Bleeding remains a serious complication associated with worse outcomes. Patients requiring a second ECMO run within 30 days have lower survival rates. |
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institution | Directory Open Access Journal |
issn | 2075-1729 |
language | English |
last_indexed | 2024-03-11T00:53:51Z |
publishDate | 2023-07-01 |
publisher | MDPI AG |
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series | Life |
spelling | doaj.art-6dae15d87bd34651a0ae53afbbc824552023-11-18T20:10:34ZengMDPI AGLife2075-17292023-07-01137158210.3390/life13071582Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center ReportAntonio Amodeo0Milena Stojanovic1Tugba Erdil2Hitendu Dave3Robert Cesnjevar4Sebastian Paal5Oliver Kretschmar6Martin Schweiger7Pediatric Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandPediatric Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandDivision of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandPediatric Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandPediatric Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandPediatric Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandChildren’s Research Center, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandPediatric Cardiovascular Surgery, Pediatric Heart Center, Department of Surgery, University Children’s Hospital Zurich, 8032 Zurich, SwitzerlandFor children born with congenital heart defects (CHDs), extracorporeal life support may be necessary. This retrospective single-center study aimed to investigate the outcomes of children with CHDs on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors. Among the 88 patients, 36 (41%) had a single-ventricle heart defect, while 52 (59%) had a biventricular defect. In total, 25 (28%) survived, with 7 (8%) in the first group and 18 (20%) in the latter. A <i>p</i>-value of 0.19 indicated no significant difference in survival rates. Children with biventricular hearts had shorter ECMO durations but longer stays in the intensive care unit. The overall rate of complications on ECMO was higher in children with a single ventricle (odds ratio [OR] 1.57, 95% confidence interval [CI] 0.67–3.7); bleeding was the most common complication in both groups. The occurrence of a second ECMO run was more frequent in patients with a single ventricle (22% vs. 9.6%). ECMO can be effective for children with congenital heart defects, including single-ventricle patients. Bleeding remains a serious complication associated with worse outcomes. Patients requiring a second ECMO run within 30 days have lower survival rates.https://www.mdpi.com/2075-1729/13/7/1582complicationscongenital heart diseaseECMOextracorporeal life supportmortalityrisk factors |
spellingShingle | Antonio Amodeo Milena Stojanovic Tugba Erdil Hitendu Dave Robert Cesnjevar Sebastian Paal Oliver Kretschmar Martin Schweiger Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report Life complications congenital heart disease ECMO extracorporeal life support mortality risk factors |
title | Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report |
title_full | Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report |
title_fullStr | Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report |
title_full_unstemmed | Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report |
title_short | Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report |
title_sort | risk factors and outcomes of children with congenital heart disease on extracorporeal membrane oxygenation a ten year single center report |
topic | complications congenital heart disease ECMO extracorporeal life support mortality risk factors |
url | https://www.mdpi.com/2075-1729/13/7/1582 |
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