Compositional plaque progression in women and men with non-obstructive coronary artery disease
Background: In coronary artery disease (CAD), plaque progression and plaque composition are associated with cardiovascular risk. Whether compositional plaque progression in non-obstructive CAD differs between women and men is less studied. Methods: We included 31 patients (42% women) with chronic no...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906724000186 |
| _version_ | 1797217103097364480 |
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| author | Caroline Annette Berge Hondros Ingela Khan Margrete Solvik Silja Hanseth Eva Kristine Ringdal Pedersen Siren Hovland Terje Hjalmar Larsen Mai Tone Lønnebakken |
| author_facet | Caroline Annette Berge Hondros Ingela Khan Margrete Solvik Silja Hanseth Eva Kristine Ringdal Pedersen Siren Hovland Terje Hjalmar Larsen Mai Tone Lønnebakken |
| author_sort | Caroline Annette Berge Hondros |
| collection | DOAJ |
| description | Background: In coronary artery disease (CAD), plaque progression and plaque composition are associated with cardiovascular risk. Whether compositional plaque progression in non-obstructive CAD differs between women and men is less studied. Methods: We included 31 patients (42% women) with chronic non-obstructive CAD from the Norwegian Registry of Invasive Cardiology, undergoing serial coronary computed tomography angiography (CCTA) on clinical indication (median inter-scan interval 1.8 [1.5–2.2] years). We performed quantitative and qualitative plaque analysis of all coronary artery segments. Results: Women were older compared to men (65 ± 8 years vs. 55 ± 12 years, p = 0.019), while there was no difference in the prevalence of hypertension, diabetes, smoking or statin treatment between groups. At baseline, women had a higher total plaque burden, more calcified plaques, and less fibro-fatty and necrotic core plaques compared to men (all p < 0.05). During follow-up, men showed faster progression of fibro-fatty plaques (4.0 ± 5.4 % per year vs. −0.6 ± 3.1 % per year, p = 0.019) and a greater reduction of fibrous plaques (-7.3 ± 6.1 % per year vs. 2.1 ± 7.2 % per year, p = 0.003) compared to women even after age adjustment. At follow-up, total plaque burden remained higher in women compared to men (24.9 ± 3.3 % vs. 21.1 ± 2.6 %, p = 0.001), while men had an increase in fibro-fatty (21.2 ± 9.3 % vs. 28.6 ± 9.8 %, p = 0.004) and necrotic core plaques (5.6 ± 3.6 % vs. 10.8 ± 7.2 %, p = 0.006), and a decrease in fibrous plaques (69.0 ± 11.9 % vs. 54.7 ± 13.7 %, p < 0.001). Women’s plaque composition remained unaltered. Conclusion: In non-obstructive CAD, serial CCTA demonstrated a higher total plaque burden and a stable plaque composition in women, while men had a faster progression of unstable low-attenuating fibro-fatty plaques.Clinical trial registration: ClinicalTrials.gov: Identifier NCT04009421. |
| first_indexed | 2024-03-08T04:50:40Z |
| format | Article |
| id | doaj.art-6dae67de532c440fbdac1c21df92314d |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-24T11:56:32Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-6dae67de532c440fbdac1c21df92314d2024-04-09T04:13:12ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672024-04-0151101352Compositional plaque progression in women and men with non-obstructive coronary artery diseaseCaroline Annette Berge Hondros0Ingela Khan1Margrete Solvik2Silja Hanseth3Eva Kristine Ringdal Pedersen4Siren Hovland5Terje Hjalmar Larsen6Mai Tone Lønnebakken7Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Department of Clinical Science, University of Bergen, P.O. Box 7804, 5020 Bergen, Norway; Corresponding author at: Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.Department of Clinical Science, University of Bergen, P.O. Box 7804, 5020 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, NorwayDepartment of Clinical Science, University of Bergen, P.O. Box 7804, 5020 Bergen, Norway; Department of Medicine, Haraldsplass Deaconess Hospital, Ulriksdal 8, 5009 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Department of Clinical Science, University of Bergen, P.O. Box 7804, 5020 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Norwegian Registry of Invasive Cardiology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Department of Biomedicine, University of Bergen, P.O. Box 7804, 5020 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway; Department of Clinical Science, University of Bergen, P.O. Box 7804, 5020 Bergen, NorwayBackground: In coronary artery disease (CAD), plaque progression and plaque composition are associated with cardiovascular risk. Whether compositional plaque progression in non-obstructive CAD differs between women and men is less studied. Methods: We included 31 patients (42% women) with chronic non-obstructive CAD from the Norwegian Registry of Invasive Cardiology, undergoing serial coronary computed tomography angiography (CCTA) on clinical indication (median inter-scan interval 1.8 [1.5–2.2] years). We performed quantitative and qualitative plaque analysis of all coronary artery segments. Results: Women were older compared to men (65 ± 8 years vs. 55 ± 12 years, p = 0.019), while there was no difference in the prevalence of hypertension, diabetes, smoking or statin treatment between groups. At baseline, women had a higher total plaque burden, more calcified plaques, and less fibro-fatty and necrotic core plaques compared to men (all p < 0.05). During follow-up, men showed faster progression of fibro-fatty plaques (4.0 ± 5.4 % per year vs. −0.6 ± 3.1 % per year, p = 0.019) and a greater reduction of fibrous plaques (-7.3 ± 6.1 % per year vs. 2.1 ± 7.2 % per year, p = 0.003) compared to women even after age adjustment. At follow-up, total plaque burden remained higher in women compared to men (24.9 ± 3.3 % vs. 21.1 ± 2.6 %, p = 0.001), while men had an increase in fibro-fatty (21.2 ± 9.3 % vs. 28.6 ± 9.8 %, p = 0.004) and necrotic core plaques (5.6 ± 3.6 % vs. 10.8 ± 7.2 %, p = 0.006), and a decrease in fibrous plaques (69.0 ± 11.9 % vs. 54.7 ± 13.7 %, p < 0.001). Women’s plaque composition remained unaltered. Conclusion: In non-obstructive CAD, serial CCTA demonstrated a higher total plaque burden and a stable plaque composition in women, while men had a faster progression of unstable low-attenuating fibro-fatty plaques.Clinical trial registration: ClinicalTrials.gov: Identifier NCT04009421.http://www.sciencedirect.com/science/article/pii/S2352906724000186Non-obstructive coronary artery diseaseCoronary computed tomography angiographySex differencesPlaque progressionPlaque composition |
| spellingShingle | Caroline Annette Berge Hondros Ingela Khan Margrete Solvik Silja Hanseth Eva Kristine Ringdal Pedersen Siren Hovland Terje Hjalmar Larsen Mai Tone Lønnebakken Compositional plaque progression in women and men with non-obstructive coronary artery disease International Journal of Cardiology: Heart & Vasculature Non-obstructive coronary artery disease Coronary computed tomography angiography Sex differences Plaque progression Plaque composition |
| title | Compositional plaque progression in women and men with non-obstructive coronary artery disease |
| title_full | Compositional plaque progression in women and men with non-obstructive coronary artery disease |
| title_fullStr | Compositional plaque progression in women and men with non-obstructive coronary artery disease |
| title_full_unstemmed | Compositional plaque progression in women and men with non-obstructive coronary artery disease |
| title_short | Compositional plaque progression in women and men with non-obstructive coronary artery disease |
| title_sort | compositional plaque progression in women and men with non obstructive coronary artery disease |
| topic | Non-obstructive coronary artery disease Coronary computed tomography angiography Sex differences Plaque progression Plaque composition |
| url | http://www.sciencedirect.com/science/article/pii/S2352906724000186 |
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