Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology
Fasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Endocrine and Metabolic Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396124000074 |
| _version_ | 1827325433970950144 |
|---|---|
| author | Matthew T.J. Halma Paul E. Marik Yusuf M. Saleeby |
| author_facet | Matthew T.J. Halma Paul E. Marik Yusuf M. Saleeby |
| author_sort | Matthew T.J. Halma |
| collection | DOAJ |
| description | Fasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore the therapeutic potential of fasting on spike protein-related pathology and the role of interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, and metformin. In conclusion, fasting, coupled with an understanding of its nuances, holds promise as a therapeutic intervention for SARS-CoV-2 spike protein related diseases; with broad implications for human health. This review presents the therapeutic possibility of using autophagy to treat spike protein related diseases, and details the interventions to deploy this therapeutic modality. |
| first_indexed | 2024-03-07T14:28:03Z |
| format | Article |
| id | doaj.art-6daea4938d7045289b308cde999c04a2 |
| institution | Directory Open Access Journal |
| issn | 2666-3961 |
| language | English |
| last_indexed | 2024-03-07T14:28:03Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj.art-6daea4938d7045289b308cde999c04a22024-03-06T05:28:49ZengElsevierEndocrine and Metabolic Science2666-39612024-03-0114100163Exploring autophagy in treating SARS-CoV-2 spike protein-related pathologyMatthew T.J. Halma0Paul E. Marik1Yusuf M. Saleeby2EbMC Squared CIC, Bath, United Kingdom; Corresponding author.Front Line COVID-19 Critical Care Alliance (FLCCC), Washington, DC, USAFront Line COVID-19 Critical Care Alliance (FLCCC), Washington, DC, USA; Carolina Holistic Medicine, Mount Pleasant, SC, USAFasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore the therapeutic potential of fasting on spike protein-related pathology and the role of interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, and metformin. In conclusion, fasting, coupled with an understanding of its nuances, holds promise as a therapeutic intervention for SARS-CoV-2 spike protein related diseases; with broad implications for human health. This review presents the therapeutic possibility of using autophagy to treat spike protein related diseases, and details the interventions to deploy this therapeutic modality.http://www.sciencedirect.com/science/article/pii/S2666396124000074FastingAutophagyLong-COVIDPost-vaccination syndromeSpike proteinMitochondria |
| spellingShingle | Matthew T.J. Halma Paul E. Marik Yusuf M. Saleeby Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology Endocrine and Metabolic Science Fasting Autophagy Long-COVID Post-vaccination syndrome Spike protein Mitochondria |
| title | Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology |
| title_full | Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology |
| title_fullStr | Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology |
| title_full_unstemmed | Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology |
| title_short | Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology |
| title_sort | exploring autophagy in treating sars cov 2 spike protein related pathology |
| topic | Fasting Autophagy Long-COVID Post-vaccination syndrome Spike protein Mitochondria |
| url | http://www.sciencedirect.com/science/article/pii/S2666396124000074 |
| work_keys_str_mv | AT matthewtjhalma exploringautophagyintreatingsarscov2spikeproteinrelatedpathology AT paulemarik exploringautophagyintreatingsarscov2spikeproteinrelatedpathology AT yusufmsaleeby exploringautophagyintreatingsarscov2spikeproteinrelatedpathology |