Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2020-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100202&tlng=en |
| _version_ | 1811229530061275136 |
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| author | Caio Julio Cesar dos Santos Fernandes Ellen Pierre de Oliveira Willian Salibe-Filho Mario Terra-Filho Carlos Vianna Poyares Jardim Luciana Tamie Kato-Morinaga Susana Hoette Rogerio de Souza |
| author_facet | Caio Julio Cesar dos Santos Fernandes Ellen Pierre de Oliveira Willian Salibe-Filho Mario Terra-Filho Carlos Vianna Poyares Jardim Luciana Tamie Kato-Morinaga Susana Hoette Rogerio de Souza |
| author_sort | Caio Julio Cesar dos Santos Fernandes |
| collection | DOAJ |
| description | OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting. |
| first_indexed | 2024-04-12T10:16:53Z |
| format | Article |
| id | doaj.art-6dafaf35e3454cb69495a0e4ed322fd4 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:16:53Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-6dafaf35e3454cb69495a0e4ed322fd42022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222020-01-017510.6061/clinics/2020/e1373Lung Cavities in Chronic Thromboembolic Pulmonary HypertensionCaio Julio Cesar dos Santos Fernandeshttps://orcid.org/0000-0002-4912-021XEllen Pierre de Oliveirahttps://orcid.org/0000-0001-8642-4725Willian Salibe-Filhohttps://orcid.org/0000-0002-2199-9525Mario Terra-Filhohttps://orcid.org/0000-0002-8642-5354Carlos Vianna Poyares Jardimhttps://orcid.org/0000-0003-0425-5548Luciana Tamie Kato-Morinagahttps://orcid.org/0000-0002-0900-2737Susana Hoettehttps://orcid.org/0000-0002-2167-1466Rogerio de Souzahttps://orcid.org/0000-0003-2789-9143OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100202&tlng=enChronic Thromboembolic Pulmonary HypertensionLung CavitiesPulmonary InfarctionChronic Granulomatous DiseasesInfection |
| spellingShingle | Caio Julio Cesar dos Santos Fernandes Ellen Pierre de Oliveira Willian Salibe-Filho Mario Terra-Filho Carlos Vianna Poyares Jardim Luciana Tamie Kato-Morinaga Susana Hoette Rogerio de Souza Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension Clinics Chronic Thromboembolic Pulmonary Hypertension Lung Cavities Pulmonary Infarction Chronic Granulomatous Diseases Infection |
| title | Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
| title_full | Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
| title_fullStr | Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
| title_full_unstemmed | Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
| title_short | Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
| title_sort | lung cavities in chronic thromboembolic pulmonary hypertension |
| topic | Chronic Thromboembolic Pulmonary Hypertension Lung Cavities Pulmonary Infarction Chronic Granulomatous Diseases Infection |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100202&tlng=en |
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