Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice
Aims and Objectives: The study was aimed to evaluate the anticonvulsant effect of hydro-alcoholic seed extract of croton tiglium in rats and mice. Materials and Methods: Forty -eight each of rats and mice of either sex were randomised into four groups and subjected to seizures induced by electr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4095/9-%207022_E(Ra)_F(P)_PF1(PAK)_PFA(AK)_PF2(PN).pdf |
| Summary: | Aims and Objectives: The study was aimed to evaluate the
anticonvulsant effect of hydro-alcoholic seed extract of croton
tiglium in rats and mice.
Materials and Methods: Forty -eight each of rats and mice of
either sex were randomised into four groups and subjected to
seizures induced by electroconvulsiometer and pentylenetetrazole.
The hydroalcoholic seed extract of croton tiglium (250 and
500mg/kg) was studied for its anticonvulsant effect using sodium
valproate (200mg/kg) as standard and distilled water as control.
The parameters observed were time for onset of HLE (Hind Limb
Extension) and duration of HLE in electrically induced seizures,
and time for onset of convulsions and duration of convulsions
in chemically induced seizures. Mortality of the animals over 24
hours was observed in both the models. For testing statistical
significance between various groups unpaired student t-test was
used.
Observations and Results: In electrically induced seizures
croton tiglium produced dose dependant prolongation of time
for onset of HLE and a reduction in duration of HLE and in
chemically induced convulsions, it prolonged time for onset of
convulsions and reduced the duration of convulsions indicating
its anticonvulsant effect in both models. However, anticonvulsant
effect was less compared to sodium valproate. There was a higher
percentage of mortality in croton tiglium group in chemically
induced convulsions when compared to sodium valproate.
Conclusion: Croton tiglium has dose dependant anticonvulsant
effect in electrically induced seizures, while in pentylenetetrazole
induced-seizures the protection is very minimal. |
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| ISSN: | 2249-782X 0973-709X |