Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice
Aims and Objectives: The study was aimed to evaluate the anticonvulsant effect of hydro-alcoholic seed extract of croton tiglium in rats and mice. Materials and Methods: Forty -eight each of rats and mice of either sex were randomised into four groups and subjected to seizures induced by electr...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4095/9-%207022_E(Ra)_F(P)_PF1(PAK)_PFA(AK)_PF2(PN).pdf |
| _version_ | 1818290567187005440 |
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| author | Raghunandan Mudium Bhanuprakash Kolasani. |
| author_facet | Raghunandan Mudium Bhanuprakash Kolasani. |
| author_sort | Raghunandan Mudium |
| collection | DOAJ |
| description | Aims and Objectives: The study was aimed to evaluate the
anticonvulsant effect of hydro-alcoholic seed extract of croton
tiglium in rats and mice.
Materials and Methods: Forty -eight each of rats and mice of
either sex were randomised into four groups and subjected to
seizures induced by electroconvulsiometer and pentylenetetrazole.
The hydroalcoholic seed extract of croton tiglium (250 and
500mg/kg) was studied for its anticonvulsant effect using sodium
valproate (200mg/kg) as standard and distilled water as control.
The parameters observed were time for onset of HLE (Hind Limb
Extension) and duration of HLE in electrically induced seizures,
and time for onset of convulsions and duration of convulsions
in chemically induced seizures. Mortality of the animals over 24
hours was observed in both the models. For testing statistical
significance between various groups unpaired student t-test was
used.
Observations and Results: In electrically induced seizures
croton tiglium produced dose dependant prolongation of time
for onset of HLE and a reduction in duration of HLE and in
chemically induced convulsions, it prolonged time for onset of
convulsions and reduced the duration of convulsions indicating
its anticonvulsant effect in both models. However, anticonvulsant
effect was less compared to sodium valproate. There was a higher
percentage of mortality in croton tiglium group in chemically
induced convulsions when compared to sodium valproate.
Conclusion: Croton tiglium has dose dependant anticonvulsant
effect in electrically induced seizures, while in pentylenetetrazole
induced-seizures the protection is very minimal. |
| first_indexed | 2024-12-13T02:30:13Z |
| format | Article |
| id | doaj.art-6db06d78c6f142c282dba32c659e9acb |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T02:30:13Z |
| publishDate | 2014-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-6db06d78c6f142c282dba32c659e9acb2022-12-22T00:02:31ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-03-0183242610.7860/JCDR/2014/7022.4095Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and MiceRaghunandan Mudium0Bhanuprakash Kolasani.1Assistant Professor, Department of Pharmacology, RIMS, Raichur, India.Assistant Professor, Department of Pharmacology, RIMS, Kadapa, India.Aims and Objectives: The study was aimed to evaluate the anticonvulsant effect of hydro-alcoholic seed extract of croton tiglium in rats and mice. Materials and Methods: Forty -eight each of rats and mice of either sex were randomised into four groups and subjected to seizures induced by electroconvulsiometer and pentylenetetrazole. The hydroalcoholic seed extract of croton tiglium (250 and 500mg/kg) was studied for its anticonvulsant effect using sodium valproate (200mg/kg) as standard and distilled water as control. The parameters observed were time for onset of HLE (Hind Limb Extension) and duration of HLE in electrically induced seizures, and time for onset of convulsions and duration of convulsions in chemically induced seizures. Mortality of the animals over 24 hours was observed in both the models. For testing statistical significance between various groups unpaired student t-test was used. Observations and Results: In electrically induced seizures croton tiglium produced dose dependant prolongation of time for onset of HLE and a reduction in duration of HLE and in chemically induced convulsions, it prolonged time for onset of convulsions and reduced the duration of convulsions indicating its anticonvulsant effect in both models. However, anticonvulsant effect was less compared to sodium valproate. There was a higher percentage of mortality in croton tiglium group in chemically induced convulsions when compared to sodium valproate. Conclusion: Croton tiglium has dose dependant anticonvulsant effect in electrically induced seizures, while in pentylenetetrazole induced-seizures the protection is very minimal.https://jcdr.net/articles/PDF/4095/9-%207022_E(Ra)_F(P)_PF1(PAK)_PFA(AK)_PF2(PN).pdfsodium valproatepentylenetetrazoleelectroconvulsiometer |
| spellingShingle | Raghunandan Mudium Bhanuprakash Kolasani. Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice Journal of Clinical and Diagnostic Research sodium valproate pentylenetetrazole electroconvulsiometer |
| title | Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice |
| title_full | Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice |
| title_fullStr | Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice |
| title_full_unstemmed | Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice |
| title_short | Anticonvulsant Effect of Hydroalcoholic Seed Extract of Croton Tiglium in Rats and Mice |
| title_sort | anticonvulsant effect of hydroalcoholic seed extract of croton tiglium in rats and mice |
| topic | sodium valproate pentylenetetrazole electroconvulsiometer |
| url | https://jcdr.net/articles/PDF/4095/9-%207022_E(Ra)_F(P)_PF1(PAK)_PFA(AK)_PF2(PN).pdf |
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