Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives

Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives

Regulation of intracellular calcium is a critical component of cardiac electrophysiology and excitation-contraction coupling. The calcium spark, the fundamental element of the intracellular calcium transient, is initiated in specialized nanodomains which co-locate the ryanodine receptors and L-type...

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Bibliographic Details
Main Authors:	Michael A. Colman, Enrique Alvarez-Lacalle, Blas Echebarria, Daisuke Sato, Henry Sutanto, Jordi Heijman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Physiology
Subjects:	cardiac electrophysiology calcium handling in cardiomyocytes excitation-contraction coupling computational modeling methods multi-scale model
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.836622/full

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