Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews
The objective of clinical trials is to answer about intervention in the real-world, for which they must be properly designed and executed by presenting the results reliably with the findings and in a clear way. OBJECTIVES: To identify the risk of bias in clinical trials about interventions for diab...
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| Format: | Article |
| Language: | English |
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Escola Bahiana de Medicina e Saúde Pública
2022-04-01
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| Series: | Journal of Evidence-Based Healthcare |
| Subjects: | |
| Online Access: | https://www5.bahiana.edu.br/index.php/evidence/article/view/3791 |
| _version_ | 1827976868977967104 |
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| author | Vânia Mozetic Valéria Barros Lucas Denadai Nilva Simeren Bueno de Moraes |
| author_facet | Vânia Mozetic Valéria Barros Lucas Denadai Nilva Simeren Bueno de Moraes |
| author_sort | Vânia Mozetic |
| collection | DOAJ |
| description |
The objective of clinical trials is to answer about intervention in the real-world, for which they must be properly designed and executed by presenting the results reliably with the findings and in a clear way. OBJECTIVES: To identify the risk of bias in clinical trials about interventions for diabetic retinopathy and/or diabetic macular edema from Cochrane systematic reviews. METHODS: A sensitive search strategy was designed to search Cochrane systematic reviews of interventions in diabetic retinopathy and diabetic macular edema. The assessment of the risk of bias was captured as presented by the author. FINDINGS: We found eight SR and one meta-analysis network totaling 116 randomized clinical trials. Our sample revealed that among the domains randomization, allocation secret, masking of participants and personnel, incomplete outcomes, selective outcomes and others, the risk of bias assessed as low ranged from 30.4 to 49.1%; unclear risk between 22 to 56% and high risk from 1 to 21.7%. CONCLUSIONS: The risk of bias in diabetic retinopathy randomized clinical trials exists in high frequency and the reader must be aware of it.
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| first_indexed | 2024-04-09T20:42:22Z |
| format | Article |
| id | doaj.art-6db35ccd611a4d5dbc105e793b7c5437 |
| institution | Directory Open Access Journal |
| issn | 2675-021X |
| language | English |
| last_indexed | 2024-04-09T20:42:22Z |
| publishDate | 2022-04-01 |
| publisher | Escola Bahiana de Medicina e Saúde Pública |
| record_format | Article |
| series | Journal of Evidence-Based Healthcare |
| spelling | doaj.art-6db35ccd611a4d5dbc105e793b7c54372023-03-29T22:06:16ZengEscola Bahiana de Medicina e Saúde PúblicaJournal of Evidence-Based Healthcare2675-021X2022-04-01410.17267/2675-021Xevidence.2022.e3791Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews Vânia Mozetic0Valéria Barros1Lucas Denadai2Nilva Simeren Bueno de Moraes3Ophthalmologist Instituto de Cardiologia Dante PazzaneseInstituto de Cardiologia Dante Pazzanese, Fundação do ABC, Universidade Federal de São Paulo (Unifesp).Ophthalmologist. Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.Ophthalmologist Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. The objective of clinical trials is to answer about intervention in the real-world, for which they must be properly designed and executed by presenting the results reliably with the findings and in a clear way. OBJECTIVES: To identify the risk of bias in clinical trials about interventions for diabetic retinopathy and/or diabetic macular edema from Cochrane systematic reviews. METHODS: A sensitive search strategy was designed to search Cochrane systematic reviews of interventions in diabetic retinopathy and diabetic macular edema. The assessment of the risk of bias was captured as presented by the author. FINDINGS: We found eight SR and one meta-analysis network totaling 116 randomized clinical trials. Our sample revealed that among the domains randomization, allocation secret, masking of participants and personnel, incomplete outcomes, selective outcomes and others, the risk of bias assessed as low ranged from 30.4 to 49.1%; unclear risk between 22 to 56% and high risk from 1 to 21.7%. CONCLUSIONS: The risk of bias in diabetic retinopathy randomized clinical trials exists in high frequency and the reader must be aware of it. https://www5.bahiana.edu.br/index.php/evidence/article/view/3791Diabetic RetinopathyDiabetic macular edemaRisk of BiasRandomized Controlled Trials as Topic |
| spellingShingle | Vânia Mozetic Valéria Barros Lucas Denadai Nilva Simeren Bueno de Moraes Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews Journal of Evidence-Based Healthcare Diabetic Retinopathy Diabetic macular edema Risk of Bias Randomized Controlled Trials as Topic |
| title | Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews |
| title_full | Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews |
| title_fullStr | Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews |
| title_full_unstemmed | Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews |
| title_short | Risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by RoB-1 tool from Cochrane systematic reviews |
| title_sort | risk of bias analysis in diabetic retinopathy randomized clinical trials evaluated by rob 1 tool from cochrane systematic reviews |
| topic | Diabetic Retinopathy Diabetic macular edema Risk of Bias Randomized Controlled Trials as Topic |
| url | https://www5.bahiana.edu.br/index.php/evidence/article/view/3791 |
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