Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients
Recent studies have proposed a connection between the individual alpha band peak frequency and the temporal resolution of visual perception in healthy human participants. This connection rests on animal studies describing oscillations in the alpha band as a mode of phasic thalamocortical information...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218302547 |
| _version_ | 1818962336661110784 |
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| author | Thomas J. Baumgarten Julia Neugebauer Georg Oeltzschner Nur-Deniz Füllenbach Gerald Kircheis Dieter Häussinger Joachim Lange Hans-Jörg Wittsack Markus Butz Alfons Schnitzler |
| author_facet | Thomas J. Baumgarten Julia Neugebauer Georg Oeltzschner Nur-Deniz Füllenbach Gerald Kircheis Dieter Häussinger Joachim Lange Hans-Jörg Wittsack Markus Butz Alfons Schnitzler |
| author_sort | Thomas J. Baumgarten |
| collection | DOAJ |
| description | Recent studies have proposed a connection between the individual alpha band peak frequency and the temporal resolution of visual perception in healthy human participants. This connection rests on animal studies describing oscillations in the alpha band as a mode of phasic thalamocortical information transfer for low-level visual stimuli, which critically relies on GABAergic interneurons.Here, we investigated the interplay of these parameters by measuring occipital alpha band peak frequency by means of magnetoencephalography, visual temporal resolution by means of behavioral testing, and occipital GABA levels by means of magnetic resonance spectroscopy. Importantly, we investigated a sample of healthy participants and patients with varying grades of hepatic encephalopathy, which are known to exhibit decreases in the investigated parameters, thus providing an increased parameter space.We found that occipital alpha band peak frequency and visual temporal resolution were positively correlated, i.e., higher occipital alpha band peak frequencies were on average related to a higher temporal resolution. Likewise, occipital alpha band peak frequency correlated positively with occipital GABA levels. However, correlations were significant only when both healthy participants and patients were included in the analysis, thereby indicating a connection of the measures on group level (instead of the individual level). These findings provide new insights into neurophysiological and neurochemical underpinnings of visual perception. Keywords: Hepatic encephalopathy, Magnetoencephalography, Alpha oscillations, Peak frequency, Magnetic resonance spectroscopy, GABA |
| first_indexed | 2024-12-20T12:27:42Z |
| format | Article |
| id | doaj.art-6db3a1164d10474abbb66db423dd4f2b |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-20T12:27:42Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-6db3a1164d10474abbb66db423dd4f2b2022-12-21T19:40:49ZengElsevierNeuroImage: Clinical2213-15822018-01-0120347356Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patientsThomas J. Baumgarten0Julia Neugebauer1Georg Oeltzschner2Nur-Deniz Füllenbach3Gerald Kircheis4Dieter Häussinger5Joachim Lange6Hans-Jörg Wittsack7Markus Butz8Alfons Schnitzler9Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany; Neuroscience Institute, New York University Langone Medical Center, New York, NY, USA; Corresponding author at: Neuroscience Institute, New York University Langone Medical Center, New York, NY, USA.Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USADepartment of Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyRecent studies have proposed a connection between the individual alpha band peak frequency and the temporal resolution of visual perception in healthy human participants. This connection rests on animal studies describing oscillations in the alpha band as a mode of phasic thalamocortical information transfer for low-level visual stimuli, which critically relies on GABAergic interneurons.Here, we investigated the interplay of these parameters by measuring occipital alpha band peak frequency by means of magnetoencephalography, visual temporal resolution by means of behavioral testing, and occipital GABA levels by means of magnetic resonance spectroscopy. Importantly, we investigated a sample of healthy participants and patients with varying grades of hepatic encephalopathy, which are known to exhibit decreases in the investigated parameters, thus providing an increased parameter space.We found that occipital alpha band peak frequency and visual temporal resolution were positively correlated, i.e., higher occipital alpha band peak frequencies were on average related to a higher temporal resolution. Likewise, occipital alpha band peak frequency correlated positively with occipital GABA levels. However, correlations were significant only when both healthy participants and patients were included in the analysis, thereby indicating a connection of the measures on group level (instead of the individual level). These findings provide new insights into neurophysiological and neurochemical underpinnings of visual perception. Keywords: Hepatic encephalopathy, Magnetoencephalography, Alpha oscillations, Peak frequency, Magnetic resonance spectroscopy, GABAhttp://www.sciencedirect.com/science/article/pii/S2213158218302547 |
| spellingShingle | Thomas J. Baumgarten Julia Neugebauer Georg Oeltzschner Nur-Deniz Füllenbach Gerald Kircheis Dieter Häussinger Joachim Lange Hans-Jörg Wittsack Markus Butz Alfons Schnitzler Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients NeuroImage: Clinical |
| title | Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients |
| title_full | Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients |
| title_fullStr | Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients |
| title_full_unstemmed | Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients |
| title_short | Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients |
| title_sort | connecting occipital alpha band peak frequency visual temporal resolution and occipital gaba levels in healthy participants and hepatic encephalopathy patients |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218302547 |
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