Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
Urinary incontinence is the major sign of menopause genitourinary syndrome and is usually related to the sexual dysfunctions. Fifty percent of menopausal women have menopausal urinary tract. Menopause genitourinary syndrome is a hypoestrogenic condition with external sexual, urological, and genital...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-04-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2023-0215 |
| _version_ | 1797208504891604992 |
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| author | Wei Lingyun Wang Wenzhen Feng Na Qiao Si |
| author_facet | Wei Lingyun Wang Wenzhen Feng Na Qiao Si |
| author_sort | Wei Lingyun |
| collection | DOAJ |
| description | Urinary incontinence is the major sign of menopause genitourinary syndrome and is usually related to the sexual dysfunctions. Fifty percent of menopausal women have menopausal urinary tract. Menopause genitourinary syndrome is a hypoestrogenic condition with external sexual, urological, and genital implications. The production of estrogen decline after menopause is an important parameter for urinary incontinence. Recently, nanotechnology has been applied as a remedial option for the genitourinary disease treatment. Silver nanoparticles were mediated by the Silybum marianum aqueous extract for the menopausal urinary incontinence treatment in ovariectomized rats in the current experiment. The green-formulated AgNPs@Silybum marianum were characterized by FT-IR, TEM, SEM, and UV–Vis. The SEM findings prove the spherical morphology with size of 15–60 nm. The ovariectomized rats were treated by AgNPs@Silybum marianum (5 and 20 µg/kg/day) for 56 days. According to the results, AgNPs@Silybum marianum increased the urinary bladder weight and reduced the body weights in comparison with the untreated rats. AgNPs@Silybum marianum rats indicated a dose-dependent amelioration for the acetylcholine contraction index. AgNPs@Silybum marianum also ameliorated the levels of serum 17β-estradiol, urinary bladder hydroxyproline, triglyceride, cholesterol, LDL, HDL, ALP, AST, and ALT in the ovariectomized rats. Based on the experiment results, the recent formulation may be applied for the menopausal urinary incontinence treatment in humans after performing the clinical research. |
| first_indexed | 2024-04-24T09:39:52Z |
| format | Article |
| id | doaj.art-6db3bf1d7ddb4e42aea47f2e53899d91 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-24T09:39:52Z |
| publishDate | 2024-04-01 |
| publisher | De Gruyter |
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| series | Open Chemistry |
| spelling | doaj.art-6db3bf1d7ddb4e42aea47f2e53899d912024-04-15T07:41:10ZengDe GruyterOpen Chemistry2391-54202024-04-01221651510.1515/chem-2023-0215Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized ratsWei Lingyun0Wang Wenzhen1Feng Na2Qiao Si3Department of Gynaecology and Obstetrics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi Province, ChinaDepartment of Gynaecology and Obstetrics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi Province, ChinaDepartment of Gynaecology and Obstetrics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi Province, ChinaDepartment of Gynaecology and Obstetrics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, Shanxi Province, ChinaUrinary incontinence is the major sign of menopause genitourinary syndrome and is usually related to the sexual dysfunctions. Fifty percent of menopausal women have menopausal urinary tract. Menopause genitourinary syndrome is a hypoestrogenic condition with external sexual, urological, and genital implications. The production of estrogen decline after menopause is an important parameter for urinary incontinence. Recently, nanotechnology has been applied as a remedial option for the genitourinary disease treatment. Silver nanoparticles were mediated by the Silybum marianum aqueous extract for the menopausal urinary incontinence treatment in ovariectomized rats in the current experiment. The green-formulated AgNPs@Silybum marianum were characterized by FT-IR, TEM, SEM, and UV–Vis. The SEM findings prove the spherical morphology with size of 15–60 nm. The ovariectomized rats were treated by AgNPs@Silybum marianum (5 and 20 µg/kg/day) for 56 days. According to the results, AgNPs@Silybum marianum increased the urinary bladder weight and reduced the body weights in comparison with the untreated rats. AgNPs@Silybum marianum rats indicated a dose-dependent amelioration for the acetylcholine contraction index. AgNPs@Silybum marianum also ameliorated the levels of serum 17β-estradiol, urinary bladder hydroxyproline, triglyceride, cholesterol, LDL, HDL, ALP, AST, and ALT in the ovariectomized rats. Based on the experiment results, the recent formulation may be applied for the menopausal urinary incontinence treatment in humans after performing the clinical research.https://doi.org/10.1515/chem-2023-021517β-estradiolovariectomized ratsmenopausal urinary incontinencesilver nanoparticlessilybum marianum leaf |
| spellingShingle | Wei Lingyun Wang Wenzhen Feng Na Qiao Si Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats Open Chemistry 17β-estradiol ovariectomized rats menopausal urinary incontinence silver nanoparticles silybum marianum leaf |
| title | Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats |
| title_full | Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats |
| title_fullStr | Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats |
| title_full_unstemmed | Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats |
| title_short | Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats |
| title_sort | effect of silver nanoparticles formulated by silybum marianum on menopausal urinary incontinence in ovariectomized rats |
| topic | 17β-estradiol ovariectomized rats menopausal urinary incontinence silver nanoparticles silybum marianum leaf |
| url | https://doi.org/10.1515/chem-2023-0215 |
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