Synthesis and Antiproliferative Evaluation of 2-Deoxy-<i>N</i>-glycosylbenzotriazoles/imidazoles

Synthesis and Antiproliferative Evaluation of 2-Deoxy-<i>N</i>-glycosylbenzotriazoles/imidazoles

A series of 2-deoxy-2-iodo-α-<span style="font-variant: small-caps;">d</span>-mannopyranosylbenzotriazoles was synthesized using the benzyl, 4,6-benzylidene and acetyl protected D-glucal in the presence of <i>N</i>-iodosuccinimide (NIS). Subsequent removal of the io...

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Bibliographic Details
Main Authors: Caleigh S. Garton, Noelle K. DeRose, Dylan Dominguez, Maria L. Turbi-Henderson, Ashley L. Lehr, Ashley D. Padilla, Scott D. Twining, Stephanie Casas, Chidozie O. Alozie, Azad L. Gucwa, Mohammed R. Elshaer, Michael De Castro
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
benzotriazole
D-glucal
cytotoxic activity
stereochemistry
heterocycles
Online Access:https://www.mdpi.com/1420-3049/26/12/3742

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