Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia
Background Schizophrenia is a severely multifactorial neuropsychiatric disorder, and the majority of cases are due to genetic variations. In this study, we evaluated the genetic association between the C-Maf-inducing protein (CMIP) gene and schizophrenia in the Han Chinese population. Methods In thi...
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PeerJ Inc.
2021-08-01
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| author | Yingli Fu Xiaojun Ren Wei Bai Qiong Yu Yaoyao Sun Yaqin Yu Na Zhou |
| author_facet | Yingli Fu Xiaojun Ren Wei Bai Qiong Yu Yaoyao Sun Yaqin Yu Na Zhou |
| author_sort | Yingli Fu |
| collection | DOAJ |
| description | Background Schizophrenia is a severely multifactorial neuropsychiatric disorder, and the majority of cases are due to genetic variations. In this study, we evaluated the genetic association between the C-Maf-inducing protein (CMIP) gene and schizophrenia in the Han Chinese population. Methods In this case-control study, 761 schizophrenia patients and 775 healthy controls were recruited. Tag single-nucleotide polymorphisms (SNPs; rs12925980, rs2287112, rs3751859 and rs77700579) from the CMIP gene were genotyped via matrix-assisted laser desorption/ionization time of flight mass spectrometry. We used logistic regression to estimate the associations between the genotypes/alleles of each SNP and schizophrenia in males and females, respectively. The in-depth link between CMIP and schizophrenia was explored through linkage disequilibrium (LD) and further haplotype analyses. False discovery rate correction was utilized to control for Type I errors caused by multiple comparisons. Results There was a significant difference in rs287112 allele frequencies between female schizophrenia patients and healthy controls after adjusting for multiple comparisons (χ2 = 12.296, Padj = 0.008). Females carrying minor allele G had 4.445 times higher risk of schizophrenia compared with people who carried the T allele (OR = 4.445, 95% CI [1.788–11.046]). Linkage-disequilibrium was not observed in the subjects, and people with haplotype TTGT of rs12925980–rs2287112–rs3751859–rs77700579 had a lower risk of schizophrenia (OR = 0.42, 95% CI [0.19–0.94]) when compared with CTGA haplotypes. However, the association did not survive false discovery rate correction. Conclusion This study identified a potential CMIP variant that may confer schizophrenia risk in the female Han Chinese population. |
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| language | English |
| last_indexed | 2024-03-09T08:07:39Z |
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| spelling | doaj.art-6db72f14c6724470baeecc9dfac391f52023-12-02T23:46:48ZengPeerJ Inc.PeerJ2167-83592021-08-019e1190710.7717/peerj.11907Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophreniaYingli Fu0Xiaojun Ren1Wei Bai2Qiong Yu3Yaoyao Sun4Yaqin Yu5Na Zhou6Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Radiation Oncology, The Second Hospital of Jilin University, Changchun, Jilin, ChinaCenter for Cognition and Brain Sciences, University of Macau, Macao SAR, ChinaDepartment of Epidemiology and Biostatistics, Jilin University, School of Public Health, Changchun, Jilin, ChinaDepartment of Epidemiology and Biostatistics, Jilin University, School of Public Health, Changchun, Jilin, ChinaDepartment of Epidemiology and Biostatistics, Jilin University, School of Public Health, Changchun, Jilin, ChinaState Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macao SAR, ChinaBackground Schizophrenia is a severely multifactorial neuropsychiatric disorder, and the majority of cases are due to genetic variations. In this study, we evaluated the genetic association between the C-Maf-inducing protein (CMIP) gene and schizophrenia in the Han Chinese population. Methods In this case-control study, 761 schizophrenia patients and 775 healthy controls were recruited. Tag single-nucleotide polymorphisms (SNPs; rs12925980, rs2287112, rs3751859 and rs77700579) from the CMIP gene were genotyped via matrix-assisted laser desorption/ionization time of flight mass spectrometry. We used logistic regression to estimate the associations between the genotypes/alleles of each SNP and schizophrenia in males and females, respectively. The in-depth link between CMIP and schizophrenia was explored through linkage disequilibrium (LD) and further haplotype analyses. False discovery rate correction was utilized to control for Type I errors caused by multiple comparisons. Results There was a significant difference in rs287112 allele frequencies between female schizophrenia patients and healthy controls after adjusting for multiple comparisons (χ2 = 12.296, Padj = 0.008). Females carrying minor allele G had 4.445 times higher risk of schizophrenia compared with people who carried the T allele (OR = 4.445, 95% CI [1.788–11.046]). Linkage-disequilibrium was not observed in the subjects, and people with haplotype TTGT of rs12925980–rs2287112–rs3751859–rs77700579 had a lower risk of schizophrenia (OR = 0.42, 95% CI [0.19–0.94]) when compared with CTGA haplotypes. However, the association did not survive false discovery rate correction. Conclusion This study identified a potential CMIP variant that may confer schizophrenia risk in the female Han Chinese population.https://peerj.com/articles/11907.pdfC-Maf-inducing proteinCMIPHaplotype analysisGene polymorphismSchizophrenia |
| spellingShingle | Yingli Fu Xiaojun Ren Wei Bai Qiong Yu Yaoyao Sun Yaqin Yu Na Zhou Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia PeerJ C-Maf-inducing protein CMIP Haplotype analysis Gene polymorphism Schizophrenia |
| title | Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia |
| title_full | Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia |
| title_fullStr | Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia |
| title_full_unstemmed | Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia |
| title_short | Association between C-Maf-inducing protein gene rs2287112 polymorphism and schizophrenia |
| title_sort | association between c maf inducing protein gene rs2287112 polymorphism and schizophrenia |
| topic | C-Maf-inducing protein CMIP Haplotype analysis Gene polymorphism Schizophrenia |
| url | https://peerj.com/articles/11907.pdf |
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