MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS
There is introduced the analysis of molecular-genetic mechanisms of tropical malaria pathogenesis and P. falciparum virulence. It is shown, that pathogenesis of tropical malaria is associated with the properties of red blood cells membrane surface (RBCs or erythrocytes) that are infected by P. falci...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2018-10-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/753 |
| _version_ | 1797723261906190336 |
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| author | A. N. Uskov A. I. Soloviev V. Yu. Kravtsov R. V. Gudkov E. V. Kolomoets A. E. Levkovskiy |
| author_facet | A. N. Uskov A. I. Soloviev V. Yu. Kravtsov R. V. Gudkov E. V. Kolomoets A. E. Levkovskiy |
| author_sort | A. N. Uskov |
| collection | DOAJ |
| description | There is introduced the analysis of molecular-genetic mechanisms of tropical malaria pathogenesis and P. falciparum virulence. It is shown, that pathogenesis of tropical malaria is associated with the properties of red blood cells membrane surface (RBCs or erythrocytes) that are infected by P. falciparum. There are «knobs structures» on membrane surface infected RBCs. Knobs structures contains a complex of P. falciparum proteins – PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1). PfEMP1 is associated with virulence of P. falciparum. Complex PfEMP1 has difficult polymorphous structure. Domains of PfEMP1 are able to associate with different cell receptors. Virulence`s individual components of the main factor are selectively sensitive to different tissues and organs. The severity of the clinical malaria infection course depends on the complex structure PfEMP1 of malaria parasites. Composition of polypeptide PfEMP1 is determined by var-complex. Nowadays there are 60 variants of var-complex. Regulation of gene expression, forming part of the var-complex, is carried out on a molecular-genetic level, cellular level, tissue level. Modern research in this area are aimed to explore genes polymorphism of the virulence`s main factor, to identify mechanism of its differential expression. Search of molecular – genetic markers is relevant to develop methods of gene diagnostic and malaria vaccine. |
| first_indexed | 2024-03-12T10:00:19Z |
| format | Article |
| id | doaj.art-6db751841e074a0287f077c1cc191acf |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T10:00:19Z |
| publishDate | 2018-10-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-6db751841e074a0287f077c1cc191acf2023-09-02T11:46:08ZrusJournal InfectologyЖурнал инфектологии2072-67322018-10-01103232910.22625/2072-6732-2018-10-3-23-29653MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESISA. N. Uskov0A. I. Soloviev1V. Yu. Kravtsov2R. V. Gudkov3E. V. Kolomoets4A. E. Levkovskiy5Детский научно-клинический центр инфекционных болезнейВоенно-медицинская академия им. С.М. КироваВоенно-медицинская академия им. С.М. КироваВоенно-медицинская академия им. С.М. КироваМедицинская служба АО «Компания Бокситов Киндия» ОК «РУСАЛ»Госпиталь «Фригия»There is introduced the analysis of molecular-genetic mechanisms of tropical malaria pathogenesis and P. falciparum virulence. It is shown, that pathogenesis of tropical malaria is associated with the properties of red blood cells membrane surface (RBCs or erythrocytes) that are infected by P. falciparum. There are «knobs structures» on membrane surface infected RBCs. Knobs structures contains a complex of P. falciparum proteins – PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1). PfEMP1 is associated with virulence of P. falciparum. Complex PfEMP1 has difficult polymorphous structure. Domains of PfEMP1 are able to associate with different cell receptors. Virulence`s individual components of the main factor are selectively sensitive to different tissues and organs. The severity of the clinical malaria infection course depends on the complex structure PfEMP1 of malaria parasites. Composition of polypeptide PfEMP1 is determined by var-complex. Nowadays there are 60 variants of var-complex. Regulation of gene expression, forming part of the var-complex, is carried out on a molecular-genetic level, cellular level, tissue level. Modern research in this area are aimed to explore genes polymorphism of the virulence`s main factor, to identify mechanism of its differential expression. Search of molecular – genetic markers is relevant to develop methods of gene diagnostic and malaria vaccine.https://journal.niidi.ru/jofin/article/view/753малярияp. falciparumгеноммолекулярно-генетическая диагностикапатогенезосновной фактор вирулентностиpfemp1 |
| spellingShingle | A. N. Uskov A. I. Soloviev V. Yu. Kravtsov R. V. Gudkov E. V. Kolomoets A. E. Levkovskiy MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS Журнал инфектологии малярия p. falciparum геном молекулярно-генетическая диагностика патогенез основной фактор вирулентности pfemp1 |
| title | MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS |
| title_full | MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS |
| title_fullStr | MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS |
| title_full_unstemmed | MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS |
| title_short | MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS |
| title_sort | molecular genetic mechanisms of plasmodium falciparum virulence and tropical malaria pathogenesis |
| topic | малярия p. falciparum геном молекулярно-генетическая диагностика патогенез основной фактор вирулентности pfemp1 |
| url | https://journal.niidi.ru/jofin/article/view/753 |
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