Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation
An efficient and facile method for the synthesis of substituted imidazoles (10a-10g) has been reported by reacting substituted aldehydes (1–7), benzil (8) and ammonium acetate [9] in presence of reuseable solid acid catalyst viz. Rice Husk Ash.SO3H (RHA.SO3H) at room temperature. The homogeneity of...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Green and Sustainable Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666086521001971 |
| _version_ | 1811297194652729344 |
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| author | Suman Sangwan Rajvir Singh Susheel Gulati Suprita Rana Jyoti Punia Kamla Malik |
| author_facet | Suman Sangwan Rajvir Singh Susheel Gulati Suprita Rana Jyoti Punia Kamla Malik |
| author_sort | Suman Sangwan |
| collection | DOAJ |
| description | An efficient and facile method for the synthesis of substituted imidazoles (10a-10g) has been reported by reacting substituted aldehydes (1–7), benzil (8) and ammonium acetate [9] in presence of reuseable solid acid catalyst viz. Rice Husk Ash.SO3H (RHA.SO3H) at room temperature. The homogeneity of compounds was confirmed by melting point and thin layer chromatography. All synthesized compounds (10a-10g) were characterized by 1H NMR and FTIR spectral techniques. The prepared catalyst has been characterized by SEM, TEM and X-ray diffraction methods. All synthesized compounds were further tested for in vitro herbicidal activity against Raphanus sativus L. seeds. The compounds were also screened for their antifungal activity against Rhizoctonia solani and Aspergillus niger by poisoned food technique method. From bio evaluation data, it was found that compounds 10c and 10a were most active against Raphanus sativus L. seeds. Compound 10g was found most active against R. solani fungus at highest concentration. Compound 10f has shown maximum percentage growth inhibition i.e. 71.89 against A. niger at 200 μg/mL concentration. |
| first_indexed | 2024-04-13T06:00:33Z |
| format | Article |
| id | doaj.art-6db838d87ade4d04bd947b766cead286 |
| institution | Directory Open Access Journal |
| issn | 2666-0865 |
| language | English |
| last_indexed | 2024-04-13T06:00:33Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Green and Sustainable Chemistry |
| spelling | doaj.art-6db838d87ade4d04bd947b766cead2862022-12-22T02:59:27ZengElsevierCurrent Research in Green and Sustainable Chemistry2666-08652022-01-015100250Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluationSuman Sangwan0Rajvir Singh1Susheel Gulati2Suprita Rana3Jyoti Punia4Kamla Malik5Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, 125004, IndiaDepartment of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, 125004, IndiaDepartment of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, 125004, India; Corresponding author.Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, 125004, IndiaDepartment of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, 125004, IndiaDepartment of Microbiology, Chaudhary Charan Singh Haryana Agricultural University, Hisar, 125004, IndiaAn efficient and facile method for the synthesis of substituted imidazoles (10a-10g) has been reported by reacting substituted aldehydes (1–7), benzil (8) and ammonium acetate [9] in presence of reuseable solid acid catalyst viz. Rice Husk Ash.SO3H (RHA.SO3H) at room temperature. The homogeneity of compounds was confirmed by melting point and thin layer chromatography. All synthesized compounds (10a-10g) were characterized by 1H NMR and FTIR spectral techniques. The prepared catalyst has been characterized by SEM, TEM and X-ray diffraction methods. All synthesized compounds were further tested for in vitro herbicidal activity against Raphanus sativus L. seeds. The compounds were also screened for their antifungal activity against Rhizoctonia solani and Aspergillus niger by poisoned food technique method. From bio evaluation data, it was found that compounds 10c and 10a were most active against Raphanus sativus L. seeds. Compound 10g was found most active against R. solani fungus at highest concentration. Compound 10f has shown maximum percentage growth inhibition i.e. 71.89 against A. niger at 200 μg/mL concentration.http://www.sciencedirect.com/science/article/pii/S2666086521001971ImidazoleRice huskRaphanus sativus L.ReuseableHerbicidal activityAntifungal activity |
| spellingShingle | Suman Sangwan Rajvir Singh Susheel Gulati Suprita Rana Jyoti Punia Kamla Malik Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation Current Research in Green and Sustainable Chemistry Imidazole Rice husk Raphanus sativus L. Reuseable Herbicidal activity Antifungal activity |
| title | Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation |
| title_full | Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation |
| title_fullStr | Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation |
| title_full_unstemmed | Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation |
| title_short | Solvent-free rice husk mediated efficient approach for synthesis of novel imidazoles and their In vitro bio evaluation |
| title_sort | solvent free rice husk mediated efficient approach for synthesis of novel imidazoles and their in vitro bio evaluation |
| topic | Imidazole Rice husk Raphanus sativus L. Reuseable Herbicidal activity Antifungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S2666086521001971 |
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