Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome
BackgroundGallstone disease is a common gastrointestinal disorder, which has previously been reported to be associated with the incidence of cardiovascular disease. We aimed to investigate the association between gallstone disease and long-term outcomes in patients with acute coronary syndrome (ACS)...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1033959/full |
| _version_ | 1828126516049870848 |
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| author | Wen Su Jie-Gao Zhu Wei-Ping Li Hui Chen Hong-Wei Li |
| author_facet | Wen Su Jie-Gao Zhu Wei-Ping Li Hui Chen Hong-Wei Li |
| author_sort | Wen Su |
| collection | DOAJ |
| description | BackgroundGallstone disease is a common gastrointestinal disorder, which has previously been reported to be associated with the incidence of cardiovascular disease. We aimed to investigate the association between gallstone disease and long-term outcomes in patients with acute coronary syndrome (ACS).Materials and methodsA total of consecutive 13,975 ACS patients were included in this analysis. Gallstone disease in our study included both gallstones and cholecystectomy. The primary endpoint was cardiac mortality. The secondary outcome was all-cause mortality. Relative risks were estimated using Cox proportional hazards regression.ResultsDuring a median follow-up period of 2.96 years, 518 (4.2%) patients without gallstone disease and 62 (3.6%) patients in those with gallstone disease suffered cardiac death. After multivariable adjustment for established risk factors, subjects with gallstone disease had decreased risks of both cardiac mortality and all-cause mortality [hazard rate ratios (HR) = 0.72, 95% CI: 0.55–0.95 and HR = 0.75, 95% CI: 0.62–0.90, respectively]. In patients with performed cholecystectomy, the associations between gallstones and risks for cardiac mortality and all-cause mortality turned out to be non-significant. HRs varied across subgroups depending on the presence of selected established risk factors.ConclusionPresence of gallstone disease was associated with a significantly decreased risk of follow-up mortality in patients with ACS. |
| first_indexed | 2024-04-11T15:35:43Z |
| format | Article |
| id | doaj.art-6db8952924e7446d884df6f1f4a13255 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T15:35:43Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-6db8952924e7446d884df6f1f4a132552022-12-22T04:15:57ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10339591033959Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndromeWen Su0Jie-Gao Zhu1Wei-Ping Li2Hui Chen3Hong-Wei Li4Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBackgroundGallstone disease is a common gastrointestinal disorder, which has previously been reported to be associated with the incidence of cardiovascular disease. We aimed to investigate the association between gallstone disease and long-term outcomes in patients with acute coronary syndrome (ACS).Materials and methodsA total of consecutive 13,975 ACS patients were included in this analysis. Gallstone disease in our study included both gallstones and cholecystectomy. The primary endpoint was cardiac mortality. The secondary outcome was all-cause mortality. Relative risks were estimated using Cox proportional hazards regression.ResultsDuring a median follow-up period of 2.96 years, 518 (4.2%) patients without gallstone disease and 62 (3.6%) patients in those with gallstone disease suffered cardiac death. After multivariable adjustment for established risk factors, subjects with gallstone disease had decreased risks of both cardiac mortality and all-cause mortality [hazard rate ratios (HR) = 0.72, 95% CI: 0.55–0.95 and HR = 0.75, 95% CI: 0.62–0.90, respectively]. In patients with performed cholecystectomy, the associations between gallstones and risks for cardiac mortality and all-cause mortality turned out to be non-significant. HRs varied across subgroups depending on the presence of selected established risk factors.ConclusionPresence of gallstone disease was associated with a significantly decreased risk of follow-up mortality in patients with ACS.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1033959/fullgallstone diseaseacute coronary syndrome (ACS)cardiac mortalityall-cause mortalitycholecystectomy |
| spellingShingle | Wen Su Jie-Gao Zhu Wei-Ping Li Hui Chen Hong-Wei Li Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome Frontiers in Cardiovascular Medicine gallstone disease acute coronary syndrome (ACS) cardiac mortality all-cause mortality cholecystectomy |
| title | Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome |
| title_full | Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome |
| title_fullStr | Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome |
| title_full_unstemmed | Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome |
| title_short | Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome |
| title_sort | gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome |
| topic | gallstone disease acute coronary syndrome (ACS) cardiac mortality all-cause mortality cholecystectomy |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1033959/full |
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