Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry
Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/18/5667 |
| _version_ | 1797517940854095872 |
|---|---|
| author | Lori Gonnet Michel Baron Michel Baltas |
| author_facet | Lori Gonnet Michel Baron Michel Baltas |
| author_sort | Lori Gonnet |
| collection | DOAJ |
| description | Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems. |
| first_indexed | 2024-03-10T07:23:14Z |
| format | Article |
| id | doaj.art-6db8f8c0993b4e028e87d64cc2e4d040 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:23:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6db8f8c0993b4e028e87d64cc2e4d0402023-11-22T14:26:40ZengMDPI AGMolecules1420-30492021-09-012618566710.3390/molecules26185667Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green ChemistryLori Gonnet0Michel Baron1Michel Baltas2IMT Mines Albi, UMR CNRS 5302, Centre Rapsodee, Campus Jarlard, Allée des Sciences, Université de Toulouse, CEDEX 09, 81013 Albi, FranceIMT Mines Albi, UMR CNRS 5302, Centre Rapsodee, Campus Jarlard, Allée des Sciences, Université de Toulouse, CEDEX 09, 81013 Albi, FranceCNRS, LCC (Laboratoire de Chimie de Coordination), Université de Toulouse, UPS, INPT, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, CEDEX 4, F-31077 Toulouse, FranceGreen Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems.https://www.mdpi.com/1420-3049/26/18/56671,2,3-triazoles1,2,4-triazolesultrasoundmedicinal chemistrygreen chemistrymechanochemistry |
| spellingShingle | Lori Gonnet Michel Baron Michel Baltas Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry Molecules 1,2,3-triazoles 1,2,4-triazoles ultrasound medicinal chemistry green chemistry mechanochemistry |
| title | Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry |
| title_full | Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry |
| title_fullStr | Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry |
| title_full_unstemmed | Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry |
| title_short | Synthesis of Biologically Relevant 1,2,3- and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry |
| title_sort | synthesis of biologically relevant 1 2 3 and 1 3 4 triazoles from classical pathway to green chemistry |
| topic | 1,2,3-triazoles 1,2,4-triazoles ultrasound medicinal chemistry green chemistry mechanochemistry |
| url | https://www.mdpi.com/1420-3049/26/18/5667 |
| work_keys_str_mv | AT lorigonnet synthesisofbiologicallyrelevant123and134triazolesfromclassicalpathwaytogreenchemistry AT michelbaron synthesisofbiologicallyrelevant123and134triazolesfromclassicalpathwaytogreenchemistry AT michelbaltas synthesisofbiologicallyrelevant123and134triazolesfromclassicalpathwaytogreenchemistry |