Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin
Deoxybostrycin (1) is an anthraquinone compound derived from the marine mangrove fungus Nigrospora sp. No. 1403 and has potential to be a lead for new drugs because of its various biological properties. A series of new derivatives (2–22) of deoxybostrycin were synthesized. The in vitro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-11-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/10/12/2715 |
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| author | Zhi-Gang She Yuhua Long Yong-Cheng Lin Sheng-Ping Chen Jue-Heng Wu Bing Yang Jia Li Li-Li Zhong Hong Chen Xun Zhu |
| author_facet | Zhi-Gang She Yuhua Long Yong-Cheng Lin Sheng-Ping Chen Jue-Heng Wu Bing Yang Jia Li Li-Li Zhong Hong Chen Xun Zhu |
| author_sort | Zhi-Gang She |
| collection | DOAJ |
| description | Deoxybostrycin (1) is an anthraquinone compound derived from the marine mangrove fungus Nigrospora sp. No. 1403 and has potential to be a lead for new drugs because of its various biological properties. A series of new derivatives (2–22) of deoxybostrycin were synthesized. The in vitro cytotoxicity of all the new compounds was tested against MDA-MB-435, HepG2 and HCT-116 cancer cell lines. Most of the compounds exhibit strong cytotoxicity with IC50 values ranging from 0.62 to 10 μM. Compounds 19, 21 display comparable cytotoxicity against MDA-MB-435 to epirubicin, the positive control. The primary screening results indicate that the deoxybostrycin derivatives might be a valuable source of new potent anticancer drug candidates. |
| first_indexed | 2024-04-14T02:01:33Z |
| format | Article |
| id | doaj.art-6dba6e44584e4cdebebcb11efb2c32a8 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T02:01:33Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-6dba6e44584e4cdebebcb11efb2c32a82022-12-22T02:18:50ZengMDPI AGMarine Drugs1660-33972012-11-0110122715272810.3390/md10122715Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite DeoxybostrycinZhi-Gang SheYuhua LongYong-Cheng LinSheng-Ping ChenJue-Heng WuBing YangJia LiLi-Li ZhongHong ChenXun ZhuDeoxybostrycin (1) is an anthraquinone compound derived from the marine mangrove fungus Nigrospora sp. No. 1403 and has potential to be a lead for new drugs because of its various biological properties. A series of new derivatives (2–22) of deoxybostrycin were synthesized. The in vitro cytotoxicity of all the new compounds was tested against MDA-MB-435, HepG2 and HCT-116 cancer cell lines. Most of the compounds exhibit strong cytotoxicity with IC50 values ranging from 0.62 to 10 μM. Compounds 19, 21 display comparable cytotoxicity against MDA-MB-435 to epirubicin, the positive control. The primary screening results indicate that the deoxybostrycin derivatives might be a valuable source of new potent anticancer drug candidates.http://www.mdpi.com/1660-3397/10/12/2715deoxybostrycin derivativesantitumor activitymarine mangroveanthraquinone |
| spellingShingle | Zhi-Gang She Yuhua Long Yong-Cheng Lin Sheng-Ping Chen Jue-Heng Wu Bing Yang Jia Li Li-Li Zhong Hong Chen Xun Zhu Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin Marine Drugs deoxybostrycin derivatives antitumor activity marine mangrove anthraquinone |
| title | Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin |
| title_full | Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin |
| title_fullStr | Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin |
| title_full_unstemmed | Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin |
| title_short | Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin |
| title_sort | synthesis and antitumor activities of derivatives of the marine mangrove fungal metabolite deoxybostrycin |
| topic | deoxybostrycin derivatives antitumor activity marine mangrove anthraquinone |
| url | http://www.mdpi.com/1660-3397/10/12/2715 |
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