Descemet’s membrane folds in ochronosis: a case report
Abstract Background We present this report of a new ophthalmic finding in a patient with ochronosis. Case presentation An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03599-x |
| _version_ | 1811200815972483072 |
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| author | Otavio de Azevedo Magalhaes Dunia Abdel Rahman Abu Hwas |
| author_facet | Otavio de Azevedo Magalhaes Dunia Abdel Rahman Abu Hwas |
| author_sort | Otavio de Azevedo Magalhaes |
| collection | DOAJ |
| description | Abstract Background We present this report of a new ophthalmic finding in a patient with ochronosis. Case presentation An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscopic examination, bilateral horizontal Descemet’s membrane folds were observed. Corneal tomography revealed irregular and asymmetric “against-the-rule” astigmatism in both eyes. Anterior segment optical coherence tomography demonstrated numerous central Descemet’s without edema or other corneal structure alterations. Conclusion This is the first report of Descemet’s membrane folds in ochronosis. These corneal findings suggest that the accumulation of homogentisic acid in the sclera leads to thickening and stiffness of this region. These alterations could remarkably decrease visual acuity owing to topographic corneal curvature alterations, especially in elderly patients. |
| first_indexed | 2024-04-12T02:11:11Z |
| format | Article |
| id | doaj.art-6dbc82152b244b62add83037e57a366d |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-12T02:11:11Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-6dbc82152b244b62add83037e57a366d2022-12-22T03:52:24ZengBMCJournal of Medical Case Reports1752-19472022-10-011611510.1186/s13256-022-03599-xDescemet’s membrane folds in ochronosis: a case reportOtavio de Azevedo Magalhaes0Dunia Abdel Rahman Abu Hwas1Department of Ophthalmology, Federal University of São Paulo (UNIFESP)Porto Alegre Eye’s Bank HospitalAbstract Background We present this report of a new ophthalmic finding in a patient with ochronosis. Case presentation An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscopic examination, bilateral horizontal Descemet’s membrane folds were observed. Corneal tomography revealed irregular and asymmetric “against-the-rule” astigmatism in both eyes. Anterior segment optical coherence tomography demonstrated numerous central Descemet’s without edema or other corneal structure alterations. Conclusion This is the first report of Descemet’s membrane folds in ochronosis. These corneal findings suggest that the accumulation of homogentisic acid in the sclera leads to thickening and stiffness of this region. These alterations could remarkably decrease visual acuity owing to topographic corneal curvature alterations, especially in elderly patients.https://doi.org/10.1186/s13256-022-03599-xAlkaptonuriaOchronosisScleral stiffnessDescemet’s membrane foldsCase report |
| spellingShingle | Otavio de Azevedo Magalhaes Dunia Abdel Rahman Abu Hwas Descemet’s membrane folds in ochronosis: a case report Journal of Medical Case Reports Alkaptonuria Ochronosis Scleral stiffness Descemet’s membrane folds Case report |
| title | Descemet’s membrane folds in ochronosis: a case report |
| title_full | Descemet’s membrane folds in ochronosis: a case report |
| title_fullStr | Descemet’s membrane folds in ochronosis: a case report |
| title_full_unstemmed | Descemet’s membrane folds in ochronosis: a case report |
| title_short | Descemet’s membrane folds in ochronosis: a case report |
| title_sort | descemet s membrane folds in ochronosis a case report |
| topic | Alkaptonuria Ochronosis Scleral stiffness Descemet’s membrane folds Case report |
| url | https://doi.org/10.1186/s13256-022-03599-x |
| work_keys_str_mv | AT otaviodeazevedomagalhaes descemetsmembranefoldsinochronosisacasereport AT duniaabdelrahmanabuhwas descemetsmembranefoldsinochronosisacasereport |