Prevalence of metabolic syndrome and its associated factors in renal transplant recipients
INTRODUCTION: The population of patients undergoing renal transplantation is considered at highrisk for developing obesity and changes in lipid and glucose metabolism, due to the use of immunosuppressive drugs and increased food freedom in the post-transplant period. OBJECTIVE: This study was design...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2012-03-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100003&lng=en&tlng=en |
| _version_ | 1811234110143725568 |
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| author | Ana Paula Simões Ferreira Teixeira Natália Maria da Silva Fernandes Gustavo Ferreira da Mata Alfredo Chaoubah Rogério Baumgratz de Paula Marcus Gomes Bastos |
| author_facet | Ana Paula Simões Ferreira Teixeira Natália Maria da Silva Fernandes Gustavo Ferreira da Mata Alfredo Chaoubah Rogério Baumgratz de Paula Marcus Gomes Bastos |
| author_sort | Ana Paula Simões Ferreira Teixeira |
| collection | DOAJ |
| description | INTRODUCTION: The population of patients undergoing renal transplantation is considered at highrisk for developing obesity and changes in lipid and glucose metabolism, due to the use of immunosuppressive drugs and increased food freedom in the post-transplant period. OBJECTIVE: This study was designed to assess the prevalence of metabolic syndrome in renal transplant recipients and to identify factors associated with its occurrence. METHODS: A cross-sectional study was performed in renal transplant patients, with more than six months of follow-up. The metabolic syndrome was diagnosed according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III. RESULTS: Among the 87 pa- tients enrolled, 39 (44.8%) presented the phenotype of metabolic syndrome. The mean age of the patients was 43.5 ± 12.1 years-old, with a predominance of male (69.0%) and white (66.7%). The mean and median times of post transplant follow-up were 64.2 ± 49.4 and 56 months, respectively. All the 12 patients who developed post-transplant diabetes mellitus also met the criteria for metabolic syndrome, which compromised the inclusion of this variable in the logistic regression. In the univariate analysis, patients with metabolic syndrome had higher mean age (p = 0.008), higher median blood level of cyclosporine (p = 0.021), higher prevalence of history of coronary disease (p = 0.023), and they were more frequent users of beta (p = 0.011) and calcium- channel blockers (p = 0.039). In the multivariate analysis, age (HR = 1.06; 95% CI=1.01-1.11, p=0.006) and use of beta-blockers (HR = 4.02; 95% CI = 1.41 - 11.4, p = 0.009) were asso- ciated with increased risk of metabolic syndrome. CONCLUSION: Metabolic syndrome was highly prevalent in the population of renal trans- plant recipients studied, and it was associated with older age, use of beta-blockers, and post-transplant diabetes mellitus. |
| first_indexed | 2024-04-12T11:31:10Z |
| format | Article |
| id | doaj.art-6dbd23bfe1bc4a359aeaff90a3573577 |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-04-12T11:31:10Z |
| publishDate | 2012-03-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-6dbd23bfe1bc4a359aeaff90a35735772022-12-22T03:35:01ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392012-03-01341162110.1590/S0101-28002012000100003S0101-28002012000100003Prevalence of metabolic syndrome and its associated factors in renal transplant recipientsAna Paula Simões Ferreira Teixeira0Natália Maria da Silva Fernandes1Gustavo Ferreira da Mata2Alfredo Chaoubah3Rogério Baumgratz de Paula4Marcus Gomes Bastos5Universidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaINTRODUCTION: The population of patients undergoing renal transplantation is considered at highrisk for developing obesity and changes in lipid and glucose metabolism, due to the use of immunosuppressive drugs and increased food freedom in the post-transplant period. OBJECTIVE: This study was designed to assess the prevalence of metabolic syndrome in renal transplant recipients and to identify factors associated with its occurrence. METHODS: A cross-sectional study was performed in renal transplant patients, with more than six months of follow-up. The metabolic syndrome was diagnosed according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III. RESULTS: Among the 87 pa- tients enrolled, 39 (44.8%) presented the phenotype of metabolic syndrome. The mean age of the patients was 43.5 ± 12.1 years-old, with a predominance of male (69.0%) and white (66.7%). The mean and median times of post transplant follow-up were 64.2 ± 49.4 and 56 months, respectively. All the 12 patients who developed post-transplant diabetes mellitus also met the criteria for metabolic syndrome, which compromised the inclusion of this variable in the logistic regression. In the univariate analysis, patients with metabolic syndrome had higher mean age (p = 0.008), higher median blood level of cyclosporine (p = 0.021), higher prevalence of history of coronary disease (p = 0.023), and they were more frequent users of beta (p = 0.011) and calcium- channel blockers (p = 0.039). In the multivariate analysis, age (HR = 1.06; 95% CI=1.01-1.11, p=0.006) and use of beta-blockers (HR = 4.02; 95% CI = 1.41 - 11.4, p = 0.009) were asso- ciated with increased risk of metabolic syndrome. CONCLUSION: Metabolic syndrome was highly prevalent in the population of renal trans- plant recipients studied, and it was associated with older age, use of beta-blockers, and post-transplant diabetes mellitus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100003&lng=en&tlng=enTransplante de RimDislipidemiasDiabetes Mellitus Tipo 2 |
| spellingShingle | Ana Paula Simões Ferreira Teixeira Natália Maria da Silva Fernandes Gustavo Ferreira da Mata Alfredo Chaoubah Rogério Baumgratz de Paula Marcus Gomes Bastos Prevalence of metabolic syndrome and its associated factors in renal transplant recipients Brazilian Journal of Nephrology Transplante de Rim Dislipidemias Diabetes Mellitus Tipo 2 |
| title | Prevalence of metabolic syndrome and its associated factors in renal transplant recipients |
| title_full | Prevalence of metabolic syndrome and its associated factors in renal transplant recipients |
| title_fullStr | Prevalence of metabolic syndrome and its associated factors in renal transplant recipients |
| title_full_unstemmed | Prevalence of metabolic syndrome and its associated factors in renal transplant recipients |
| title_short | Prevalence of metabolic syndrome and its associated factors in renal transplant recipients |
| title_sort | prevalence of metabolic syndrome and its associated factors in renal transplant recipients |
| topic | Transplante de Rim Dislipidemias Diabetes Mellitus Tipo 2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002012000100003&lng=en&tlng=en |
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