Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association
Abstract We report on a 52‐year‐old Brazilian immigrant woman with past histories of chronic kidney disease and uveitis, presenting with symptomatic atrioventricular block. Her country of origin being endemic for Trypanosoma cruzi infection, we suspected Chagas disease as the aetiology, diagnosis of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-02-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13771 |
| _version_ | 1798025013185478656 |
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| author | Shun Nakagama Katherine Candray Tasuku Yamamoto Yuta Tsugeno Yu Nakagama Yasutoshi Kido Yuko Nitahara Yasuhiro Maejima Tetsuo Sasano |
| author_facet | Shun Nakagama Katherine Candray Tasuku Yamamoto Yuta Tsugeno Yu Nakagama Yasutoshi Kido Yuko Nitahara Yasuhiro Maejima Tetsuo Sasano |
| author_sort | Shun Nakagama |
| collection | DOAJ |
| description | Abstract We report on a 52‐year‐old Brazilian immigrant woman with past histories of chronic kidney disease and uveitis, presenting with symptomatic atrioventricular block. Her country of origin being endemic for Trypanosoma cruzi infection, we suspected Chagas disease as the aetiology, diagnosis of which was confirmed by serological tests. Further systemic workup identified an emerging nodular lesion in the lung, which turned out to be a sarcoid epithelioid granuloma on biopsy. Involvement of the kidneys and eyes was suggestive of systemic extension of the lung sarcoidosis. Although imaging modalities did not detect inflammatory foci in the myocardium, the rare coexistence of histologically proven sarcoidosis raised the intriguing concept of cardiac manifestation having arisen from two possibly overlapping aetiologies: Chagas disease and cardiac sarcoidosis. The case highlights a treatment dilemma increasingly likely to be encountered in this globalized world, and also raises the potential, but intriguing, association of these two diseases. |
| first_indexed | 2024-04-11T18:11:54Z |
| format | Article |
| id | doaj.art-6dbd6a72c2824cab8b22519ad1058f74 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-11T18:11:54Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-6dbd6a72c2824cab8b22519ad1058f742022-12-22T04:10:04ZengWileyESC Heart Failure2055-58222022-02-019176176510.1002/ehf2.13771Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential associationShun Nakagama0Katherine Candray1Tasuku Yamamoto2Yuta Tsugeno3Yu Nakagama4Yasutoshi Kido5Yuko Nitahara6Yasuhiro Maejima7Tetsuo Sasano8Department of Cardiovascular Medicine, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo JapanDepartment of Parasitology and Research Center for Infectious Disease Sciences Osaka City University Osaka JapanDepartment of Cardiovascular Medicine, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo JapanDepartment of Comprehensive Pathology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo JapanDepartment of Parasitology and Research Center for Infectious Disease Sciences Osaka City University Osaka JapanDepartment of Parasitology and Research Center for Infectious Disease Sciences Osaka City University Osaka JapanDepartment of Parasitology and Research Center for Infectious Disease Sciences Osaka City University Osaka JapanDepartment of Cardiovascular Medicine, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo JapanDepartment of Cardiovascular Medicine, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo JapanAbstract We report on a 52‐year‐old Brazilian immigrant woman with past histories of chronic kidney disease and uveitis, presenting with symptomatic atrioventricular block. Her country of origin being endemic for Trypanosoma cruzi infection, we suspected Chagas disease as the aetiology, diagnosis of which was confirmed by serological tests. Further systemic workup identified an emerging nodular lesion in the lung, which turned out to be a sarcoid epithelioid granuloma on biopsy. Involvement of the kidneys and eyes was suggestive of systemic extension of the lung sarcoidosis. Although imaging modalities did not detect inflammatory foci in the myocardium, the rare coexistence of histologically proven sarcoidosis raised the intriguing concept of cardiac manifestation having arisen from two possibly overlapping aetiologies: Chagas disease and cardiac sarcoidosis. The case highlights a treatment dilemma increasingly likely to be encountered in this globalized world, and also raises the potential, but intriguing, association of these two diseases.https://doi.org/10.1002/ehf2.13771Atrioventricular blockInflammatory cardiomyopathySarcoidosisChagas diseaseTrypanosoma cruziLatin America |
| spellingShingle | Shun Nakagama Katherine Candray Tasuku Yamamoto Yuta Tsugeno Yu Nakagama Yasutoshi Kido Yuko Nitahara Yasuhiro Maejima Tetsuo Sasano Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association ESC Heart Failure Atrioventricular block Inflammatory cardiomyopathy Sarcoidosis Chagas disease Trypanosoma cruzi Latin America |
| title | Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association |
| title_full | Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association |
| title_fullStr | Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association |
| title_full_unstemmed | Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association |
| title_short | Inflammatory cardiomyopathy of possibly overlapping aetiology: a case posing treatment dilemma and potential association |
| title_sort | inflammatory cardiomyopathy of possibly overlapping aetiology a case posing treatment dilemma and potential association |
| topic | Atrioventricular block Inflammatory cardiomyopathy Sarcoidosis Chagas disease Trypanosoma cruzi Latin America |
| url | https://doi.org/10.1002/ehf2.13771 |
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