A novel protein-drug conjugate, SSH20, demonstrates significant efficacy in caveolin-1-expressing tumors

A novel protein-drug conjugate, SSH20, demonstrates significant efficacy in caveolin-1-expressing tumors

In recent years, human serum albumin (HSA) has been characterized as an ideal drug carrier in the cancer arena. Caveolin-1 (Cav-1) has been established as the principal structural protein of caveolae and, thus, critical for caveolae-mediated endocytosis. Cav-1 has been shown to be overexpressed in c...

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Bibliographic Details
Main Authors: Ryan Robb, Jimmy Chun-Tien Kuo, Yang Liu, Sergio Corrales-Guerrero, Tiantian Cui, Ahmad Hegazi, Gregory Nagy, Robert J. Lee, Terence M. Williams
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
SSH20
lung cancer
pancreatic cancer
caveolin-1
albumin
SN-38
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001108

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