A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms
Abstract We aimed to investigate the causality between potentially modifiable risk factors and the risk of intracranial aneurysm. Genetic instruments for 51 modifiable factors and intracranial aneurysm data were obtained from recently published genome-wide association studies. We applied two-sample...
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| Format: | Article |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11720-9 |
| _version_ | 1811253251314548736 |
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| author | Danyang Tian Linjing Zhang Zhenhuang Zhuang Tao Huang Dongsheng Fan |
| author_facet | Danyang Tian Linjing Zhang Zhenhuang Zhuang Tao Huang Dongsheng Fan |
| author_sort | Danyang Tian |
| collection | DOAJ |
| description | Abstract We aimed to investigate the causality between potentially modifiable risk factors and the risk of intracranial aneurysm. Genetic instruments for 51 modifiable factors and intracranial aneurysm data were obtained from recently published genome-wide association studies. We applied two-sample Mendelian randomization methods to investigate their causal relationships. Genetically predicted cigarettes per day, smoking initiation, systolic blood pressure, hypertension and body fat percentage were significantly associated with an increased risk of intracranial aneurysm [odds ratios (OR) 2.67, 95% confidence interval (CI) 1.75–4.07, p = 5.36 × 10–6, OR 1.53, 95% CI 1.32–1.77, p = 9.58 × 10–9, OR 1.05, 95% CI 1.02–1.08, p = 1.18 × 10–3, OR 1.65, 95% CI 1.19–2.28, p = 2.56 × 10–3 and OR 1.29, 95% CI 1.11–1.52, p = 1.33 × 10–3, respectively]. Type 2 diabetes mellitus was significantly associated with a decreased risk of intracranial aneurysm (OR 0.89, 95% CI 0.83–0.95, p = 8.54 × 10–4). Body fat percentage was significantly associated with subarachnoid haemorrhage (p = 5.70 × 10–5). This study provided genetic evidence of causal effects of smoking, blood pressure, type 2 diabetes mellitus and obesity on the risk of intracranial aneurysm. |
| first_indexed | 2024-04-12T16:48:06Z |
| format | Article |
| id | doaj.art-6dbdfcfcde534101aead54ca3ac258c2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:48:06Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-6dbdfcfcde534101aead54ca3ac258c22022-12-22T03:24:31ZengNature PortfolioScientific Reports2045-23222022-05-011211810.1038/s41598-022-11720-9A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysmsDanyang Tian0Linjing Zhang1Zhenhuang Zhuang2Tao Huang3Dongsheng Fan4Department of Neurology, Peking University Third HospitalDepartment of Neurology, Peking University Third HospitalDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityDepartment of Neurology, Peking University Third HospitalAbstract We aimed to investigate the causality between potentially modifiable risk factors and the risk of intracranial aneurysm. Genetic instruments for 51 modifiable factors and intracranial aneurysm data were obtained from recently published genome-wide association studies. We applied two-sample Mendelian randomization methods to investigate their causal relationships. Genetically predicted cigarettes per day, smoking initiation, systolic blood pressure, hypertension and body fat percentage were significantly associated with an increased risk of intracranial aneurysm [odds ratios (OR) 2.67, 95% confidence interval (CI) 1.75–4.07, p = 5.36 × 10–6, OR 1.53, 95% CI 1.32–1.77, p = 9.58 × 10–9, OR 1.05, 95% CI 1.02–1.08, p = 1.18 × 10–3, OR 1.65, 95% CI 1.19–2.28, p = 2.56 × 10–3 and OR 1.29, 95% CI 1.11–1.52, p = 1.33 × 10–3, respectively]. Type 2 diabetes mellitus was significantly associated with a decreased risk of intracranial aneurysm (OR 0.89, 95% CI 0.83–0.95, p = 8.54 × 10–4). Body fat percentage was significantly associated with subarachnoid haemorrhage (p = 5.70 × 10–5). This study provided genetic evidence of causal effects of smoking, blood pressure, type 2 diabetes mellitus and obesity on the risk of intracranial aneurysm.https://doi.org/10.1038/s41598-022-11720-9 |
| spellingShingle | Danyang Tian Linjing Zhang Zhenhuang Zhuang Tao Huang Dongsheng Fan A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms Scientific Reports |
| title | A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms |
| title_full | A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms |
| title_fullStr | A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms |
| title_full_unstemmed | A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms |
| title_short | A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms |
| title_sort | two sample mendelian randomization analysis of modifiable risk factors and intracranial aneurysms |
| url | https://doi.org/10.1038/s41598-022-11720-9 |
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