Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension
We determined high concentrations of arginine and polyamines (putrescine, spermidine, and spermine) in yuzu (Citrus junos) seeds. Yuzu produces large quantities of limonoids. We fed limonoid aglycones extracted from yuzu seeds and commercial spermine as a polyamine to Sandhoff disease (SD) mice with...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617305650 |
| _version_ | 1818410004363870208 |
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| author | Mayumi Minamisawa Kyoko Suzuki Gota Kawai Akira Yamaguchi Shoji Yamanaka |
| author_facet | Mayumi Minamisawa Kyoko Suzuki Gota Kawai Akira Yamaguchi Shoji Yamanaka |
| author_sort | Mayumi Minamisawa |
| collection | DOAJ |
| description | We determined high concentrations of arginine and polyamines (putrescine, spermidine, and spermine) in yuzu (Citrus junos) seeds. Yuzu produces large quantities of limonoids. We fed limonoid aglycones extracted from yuzu seeds and commercial spermine as a polyamine to Sandhoff disease (SD) mice with abnormal glycolipid metabolism and autosomal recessive inheritance, as found in humans. Ingestion of limonoid aglycones and spermine by SD mice extended their longevity by about 10–12%, where it alleviated inflammation of the central nervous system. After administering limonoid aglycones or limonoid aglycones/spermine, analyses of the bacterial flora in the feces based on 16S rDNA indicated changes in the relative ratio between Bacteroidetes (Bacteroidales and Lactobacillus) and Firmicutes (Clostridiales and Erysipelotrichaceae). In both SD and wild-type mice, the amount of short-chain fatty acids produced by the bacterial flora increased according to the intake of limonoid aglycones and spermine. |
| first_indexed | 2024-12-14T10:08:37Z |
| format | Article |
| id | doaj.art-6dbe3c98a3744e9680868284183bbd80 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T10:08:37Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6dbe3c98a3744e9680868284183bbd802022-12-21T23:07:05ZengElsevierJournal of Functional Foods1756-46462017-11-0138591600Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extensionMayumi Minamisawa0Kyoko Suzuki1Gota Kawai2Akira Yamaguchi3Shoji Yamanaka4Dept. Chemistry Education Center, Faculty of Advanced Engineering, Chiba Institute of Technology, 2-1-1, Shibazono, Narashino, Chiba, Japan; Corresponding author.Dept. Psychiatry Sch. Med., Yokohama City Univ., Yokohama, Kanagawa, JapanDept. Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba, JapanDept. Pathol., Yokohama City Univ., Yokohama, Kanagawa, Japan, Yokohama, Kanagawa, JapanDept. Pathol., Yokohama City Univ., Yokohama, Kanagawa, Japan, Yokohama, Kanagawa, JapanWe determined high concentrations of arginine and polyamines (putrescine, spermidine, and spermine) in yuzu (Citrus junos) seeds. Yuzu produces large quantities of limonoids. We fed limonoid aglycones extracted from yuzu seeds and commercial spermine as a polyamine to Sandhoff disease (SD) mice with abnormal glycolipid metabolism and autosomal recessive inheritance, as found in humans. Ingestion of limonoid aglycones and spermine by SD mice extended their longevity by about 10–12%, where it alleviated inflammation of the central nervous system. After administering limonoid aglycones or limonoid aglycones/spermine, analyses of the bacterial flora in the feces based on 16S rDNA indicated changes in the relative ratio between Bacteroidetes (Bacteroidales and Lactobacillus) and Firmicutes (Clostridiales and Erysipelotrichaceae). In both SD and wild-type mice, the amount of short-chain fatty acids produced by the bacterial flora increased according to the intake of limonoid aglycones and spermine.http://www.sciencedirect.com/science/article/pii/S1756464617305650Yuzu (Citrus junos)LimonoidsPolyaminesSandhoff disease miceIntestinal flora |
| spellingShingle | Mayumi Minamisawa Kyoko Suzuki Gota Kawai Akira Yamaguchi Shoji Yamanaka Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension Journal of Functional Foods Yuzu (Citrus junos) Limonoids Polyamines Sandhoff disease mice Intestinal flora |
| title | Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension |
| title_full | Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension |
| title_fullStr | Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension |
| title_full_unstemmed | Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension |
| title_short | Functional evaluation of yuzu (Citrus junos) extracts containing limonoids and polyamine for life extension |
| title_sort | functional evaluation of yuzu citrus junos extracts containing limonoids and polyamine for life extension |
| topic | Yuzu (Citrus junos) Limonoids Polyamines Sandhoff disease mice Intestinal flora |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617305650 |
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