Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair
The repair of critical bone defects is a hotspot of orthopedic research. With the development of bone tissue engineering (BTE), there is increasing evidence showing that the combined application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/12/7/716 |
| _version_ | 1797445271365353472 |
|---|---|
| author | Dongxue Wang Hong Cao Weizhong Hua Lu Gao Yu Yuan Xuchang Zhou Zhipeng Zeng |
| author_facet | Dongxue Wang Hong Cao Weizhong Hua Lu Gao Yu Yuan Xuchang Zhou Zhipeng Zeng |
| author_sort | Dongxue Wang |
| collection | DOAJ |
| description | The repair of critical bone defects is a hotspot of orthopedic research. With the development of bone tissue engineering (BTE), there is increasing evidence showing that the combined application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes, with hydrogels, scaffolds, and other bioactive materials has made great progress, exhibiting a good potential for bone regeneration. Recent studies have found that miRNAs, proteins, and other cargo loaded in EVs are key factors in promoting osteogenesis and angiogenesis. In BTE, the expression profile of the intrinsic cargo of EVs can be changed by modifying the gene expression of MSCs to obtain EVs with enhanced osteogenic activity and ultimately enhance the osteoinductive ability of bone graft materials. However, the current research on MSC-EVs for repairing bone defects is still in its infancy, and the underlying mechanism remains unclear. Therefore, in this review, the effect of bioactive materials such as hydrogels and scaffolds combined with MSC-EVs in repairing bone defects is summarized, and the mechanism of MSC-EVs promoting bone defect repair by delivering active molecules such as internal miRNAs is further elucidated, which provides a theoretical basis and reference for the clinical application of MSC-EVs in repairing bone defects. |
| first_indexed | 2024-03-09T13:24:23Z |
| format | Article |
| id | doaj.art-6dbfc34dfd4940739d2a67d7a2e45e32 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T13:24:23Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-6dbfc34dfd4940739d2a67d7a2e45e322023-11-30T21:26:19ZengMDPI AGMembranes2077-03752022-07-0112771610.3390/membranes12070716Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect RepairDongxue Wang0Hong Cao1Weizhong Hua2Lu Gao3Yu Yuan4Xuchang Zhou5Zhipeng Zeng6School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaThe repair of critical bone defects is a hotspot of orthopedic research. With the development of bone tissue engineering (BTE), there is increasing evidence showing that the combined application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes, with hydrogels, scaffolds, and other bioactive materials has made great progress, exhibiting a good potential for bone regeneration. Recent studies have found that miRNAs, proteins, and other cargo loaded in EVs are key factors in promoting osteogenesis and angiogenesis. In BTE, the expression profile of the intrinsic cargo of EVs can be changed by modifying the gene expression of MSCs to obtain EVs with enhanced osteogenic activity and ultimately enhance the osteoinductive ability of bone graft materials. However, the current research on MSC-EVs for repairing bone defects is still in its infancy, and the underlying mechanism remains unclear. Therefore, in this review, the effect of bioactive materials such as hydrogels and scaffolds combined with MSC-EVs in repairing bone defects is summarized, and the mechanism of MSC-EVs promoting bone defect repair by delivering active molecules such as internal miRNAs is further elucidated, which provides a theoretical basis and reference for the clinical application of MSC-EVs in repairing bone defects.https://www.mdpi.com/2077-0375/12/7/716bone graftexosomesextracellular vesiclesmesenchymal stem cellstissue engineering |
| spellingShingle | Dongxue Wang Hong Cao Weizhong Hua Lu Gao Yu Yuan Xuchang Zhou Zhipeng Zeng Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair Membranes bone graft exosomes extracellular vesicles mesenchymal stem cells tissue engineering |
| title | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair |
| title_full | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair |
| title_fullStr | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair |
| title_short | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair |
| title_sort | mesenchymal stem cell derived extracellular vesicles for bone defect repair |
| topic | bone graft exosomes extracellular vesicles mesenchymal stem cells tissue engineering |
| url | https://www.mdpi.com/2077-0375/12/7/716 |
| work_keys_str_mv | AT dongxuewang mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair AT hongcao mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair AT weizhonghua mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair AT lugao mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair AT yuyuan mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair AT xuchangzhou mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair AT zhipengzeng mesenchymalstemcellderivedextracellularvesiclesforbonedefectrepair |