Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis
Necrotizing ulcerative periodontitis (NUP) is a painful and debilitating condition seen mostly in an immunocompromised state. Although squamous cell carcinoma (SCC) on gingiva is not uncommon, its presentation as a benign necrotizing lesion on gingiva is rare. Such presentations may lead to delayed...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=1;spage=61;epage=64;aulast=Khan |
| _version_ | 1818954705798168576 |
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| author | Saif Khan Kafil Akhtar Abdul Ahad Jaiti Uppal |
| author_facet | Saif Khan Kafil Akhtar Abdul Ahad Jaiti Uppal |
| author_sort | Saif Khan |
| collection | DOAJ |
| description | Necrotizing ulcerative periodontitis (NUP) is a painful and debilitating condition seen mostly in an immunocompromised state. Although squamous cell carcinoma (SCC) on gingiva is not uncommon, its presentation as a benign necrotizing lesion on gingiva is rare. Such presentations may lead to delayed diagnosis and poor prognosis. This report describes a case of a 34-year-old male presenting clinically with NUP around mandibular posterior teeth. Clinical features were misleading, but the histological findings established the diagnosis of well-differentiated SCC. Immunohistochemistry also showed features of epithelial–mesenchymal transition with decreased expression of E-cadherin and increased vimentin expression showing local invasion and metastasis. The patient was referred to the oncology department for evaluation of possible metastasis and further management of carcinoma. |
| first_indexed | 2024-12-20T10:26:25Z |
| format | Article |
| id | doaj.art-6dc14cd49aba49f7a368811a7b57cc19 |
| institution | Directory Open Access Journal |
| issn | 0972-124X |
| language | English |
| last_indexed | 2024-12-20T10:26:25Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj.art-6dc14cd49aba49f7a368811a7b57cc192022-12-21T19:43:49ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2021-01-01251616410.4103/jisp.jisp_175_20Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitisSaif KhanKafil AkhtarAbdul AhadJaiti UppalNecrotizing ulcerative periodontitis (NUP) is a painful and debilitating condition seen mostly in an immunocompromised state. Although squamous cell carcinoma (SCC) on gingiva is not uncommon, its presentation as a benign necrotizing lesion on gingiva is rare. Such presentations may lead to delayed diagnosis and poor prognosis. This report describes a case of a 34-year-old male presenting clinically with NUP around mandibular posterior teeth. Clinical features were misleading, but the histological findings established the diagnosis of well-differentiated SCC. Immunohistochemistry also showed features of epithelial–mesenchymal transition with decreased expression of E-cadherin and increased vimentin expression showing local invasion and metastasis. The patient was referred to the oncology department for evaluation of possible metastasis and further management of carcinoma.http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=1;spage=61;epage=64;aulast=Khangingivaimmunohistochemistryperiodontal diseasesquamous cell carcinoma |
| spellingShingle | Saif Khan Kafil Akhtar Abdul Ahad Jaiti Uppal Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis Journal of Indian Society of Periodontology gingiva immunohistochemistry periodontal disease squamous cell carcinoma |
| title | Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis |
| title_full | Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis |
| title_fullStr | Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis |
| title_full_unstemmed | Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis |
| title_short | Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis |
| title_sort | gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis |
| topic | gingiva immunohistochemistry periodontal disease squamous cell carcinoma |
| url | http://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=1;spage=61;epage=64;aulast=Khan |
| work_keys_str_mv | AT saifkhan gingivalsquamouscellcarcinomamasqueradingasnecrotizingulcerativeperiodontitis AT kafilakhtar gingivalsquamouscellcarcinomamasqueradingasnecrotizingulcerativeperiodontitis AT abdulahad gingivalsquamouscellcarcinomamasqueradingasnecrotizingulcerativeperiodontitis AT jaitiuppal gingivalsquamouscellcarcinomamasqueradingasnecrotizingulcerativeperiodontitis |