Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid
Background: Clinical attachment level (CAL), alveolar bone loss, and periodontal pockets constitute the major signs of periodontitis. The interaction between the host and the bacteria that forms a biofilm on the tooth surface is one of the major etiologies of periodontal disorders. Aim: The aim of t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | SRM Journal of Research in Dental Sciences |
| Subjects: | |
| Online Access: | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2023;volume=14;issue=4;spage=194;epage=198;aulast=Jadhav |
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| author | Ashwini Jadhav Surekha Ramrao Rathod Abhay P Kolte Palak Kasliwal |
| author_facet | Ashwini Jadhav Surekha Ramrao Rathod Abhay P Kolte Palak Kasliwal |
| author_sort | Ashwini Jadhav |
| collection | DOAJ |
| description | Background: Clinical attachment level (CAL), alveolar bone loss, and periodontal pockets constitute the major signs of periodontitis. The interaction between the host and the bacteria that forms a biofilm on the tooth surface is one of the major etiologies of periodontal disorders. Aim: The aim of this study was to assess interleukin-35 (IL-35) levels pre and post nonsurgical periodontal therapy (NSPT) in healthy individuals and gingivitis and periodontitis patients. Materials and Methods: IL-35 level in gingival crevicular fluid (GCF) and clinical parameters were assessed in 60 individuals. Biochemical analysis was done by enzyme-linked immunosorbent assay. Individuals in Group I were in good health; those in Groups II and III had gingivitis and periodontitis, respectively. Study individuals were evaluated at baseline and 3 months after NSPT. Results: Group III differed from Group II in that it had higher CAL (7.60), plaque index (2.8929), and periodontal probing depth (5.8500 mm) values, as well as lower papillary bleeding index (2.1170) and gingival index (2.1085) values. The concentrations of IL-35 in GCF varied among the groups, with Group III having the lowest concentrations and rising gradually to Groups II and I. In addition, from baseline to 3 months, the IL-35 levels in GCF significantly decreased in both Groups II and III. The results show that Groups II and III have lower GCF levels of IL-35 than Group I, suggesting that IL-35 is a major factor in the development of periodontal diseases. Conclusion: Group I had considerably greater GCF IL-35 values than Group II and III both before and after NSPT. |
| first_indexed | 2024-04-24T13:04:02Z |
| format | Article |
| id | doaj.art-6dc172eedc0e448ab6e9865fe064c508 |
| institution | Directory Open Access Journal |
| issn | 2772-5243 2772-5251 |
| language | English |
| last_indexed | 2024-04-24T13:04:02Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | SRM Journal of Research in Dental Sciences |
| spelling | doaj.art-6dc172eedc0e448ab6e9865fe064c5082024-04-05T08:39:53ZengWolters Kluwer Medknow PublicationsSRM Journal of Research in Dental Sciences2772-52432772-52512023-01-0114419419810.4103/srmjrds.srmjrds_150_23Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluidAshwini JadhavSurekha Ramrao RathodAbhay P KoltePalak KasliwalBackground: Clinical attachment level (CAL), alveolar bone loss, and periodontal pockets constitute the major signs of periodontitis. The interaction between the host and the bacteria that forms a biofilm on the tooth surface is one of the major etiologies of periodontal disorders. Aim: The aim of this study was to assess interleukin-35 (IL-35) levels pre and post nonsurgical periodontal therapy (NSPT) in healthy individuals and gingivitis and periodontitis patients. Materials and Methods: IL-35 level in gingival crevicular fluid (GCF) and clinical parameters were assessed in 60 individuals. Biochemical analysis was done by enzyme-linked immunosorbent assay. Individuals in Group I were in good health; those in Groups II and III had gingivitis and periodontitis, respectively. Study individuals were evaluated at baseline and 3 months after NSPT. Results: Group III differed from Group II in that it had higher CAL (7.60), plaque index (2.8929), and periodontal probing depth (5.8500 mm) values, as well as lower papillary bleeding index (2.1170) and gingival index (2.1085) values. The concentrations of IL-35 in GCF varied among the groups, with Group III having the lowest concentrations and rising gradually to Groups II and I. In addition, from baseline to 3 months, the IL-35 levels in GCF significantly decreased in both Groups II and III. The results show that Groups II and III have lower GCF levels of IL-35 than Group I, suggesting that IL-35 is a major factor in the development of periodontal diseases. Conclusion: Group I had considerably greater GCF IL-35 values than Group II and III both before and after NSPT.http://www.srmjrds.in/article.asp?issn=0976-433X;year=2023;volume=14;issue=4;spage=194;epage=198;aulast=Jadhavgingival crevicular fluidgingivitisinterleukin-35periodontal diseases |
| spellingShingle | Ashwini Jadhav Surekha Ramrao Rathod Abhay P Kolte Palak Kasliwal Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid SRM Journal of Research in Dental Sciences gingival crevicular fluid gingivitis interleukin-35 periodontal diseases |
| title | Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid |
| title_full | Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid |
| title_fullStr | Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid |
| title_full_unstemmed | Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid |
| title_short | Effect of nonsurgical periodontal therapy on interleukin-35 level in gingival crevicular fluid |
| title_sort | effect of nonsurgical periodontal therapy on interleukin 35 level in gingival crevicular fluid |
| topic | gingival crevicular fluid gingivitis interleukin-35 periodontal diseases |
| url | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2023;volume=14;issue=4;spage=194;epage=198;aulast=Jadhav |
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