Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central...
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MDPI AG
2021-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/5007 |
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| author | Maria Albanese Stefano Di Girolamo Lorenzo Silvani Eleonora Ciaschi Barbara Chiaramonte Matteo Conti Francesco Maria Passali Battista Di Gioia Nicola Biagio Mercuri Arianna Di Stadio |
| author_facet | Maria Albanese Stefano Di Girolamo Lorenzo Silvani Eleonora Ciaschi Barbara Chiaramonte Matteo Conti Francesco Maria Passali Battista Di Gioia Nicola Biagio Mercuri Arianna Di Stadio |
| author_sort | Maria Albanese |
| collection | DOAJ |
| description | Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time. |
| first_indexed | 2024-03-10T05:59:45Z |
| format | Article |
| id | doaj.art-6dc30fbe17294f2eb0acb7ea0347f8e3 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:59:45Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6dc30fbe17294f2eb0acb7ea0347f8e32023-11-22T21:05:56ZengMDPI AGJournal of Clinical Medicine2077-03832021-10-011021500710.3390/jcm10215007Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control StudyMaria Albanese0Stefano Di Girolamo1Lorenzo Silvani2Eleonora Ciaschi3Barbara Chiaramonte4Matteo Conti5Francesco Maria Passali6Battista Di Gioia7Nicola Biagio Mercuri8Arianna Di Stadio9Regional Referral Headache Center, Neurology Unit, University Hospital “Tor Vergata”, 00133 Rome, ItalyUnit of Otorhinolaryngology, Department of Clinical Sciences and Translation Medicine, Tor Vergata University, 00133 Rome, ItalyUnit of Otorhinolaryngology, Department of Clinical Sciences and Translation Medicine, Tor Vergata University, 00133 Rome, ItalyUnit of Otorhinolaryngology, Department of Clinical Sciences and Translation Medicine, Tor Vergata University, 00133 Rome, ItalyINAIL Consulenza Statistico Attuariale, Settore Tariffe, 00143 Rome, ItalyRegional Referral Headache Center, Neurology Unit, University Hospital “Tor Vergata”, 00133 Rome, ItalyUnit of Otorhinolaryngology, Department of Clinical Sciences and Translation Medicine, Tor Vergata University, 00133 Rome, ItalyRegional Referral Headache Center, Neurology Unit, University Hospital “Tor Vergata”, 00133 Rome, ItalyRegional Referral Headache Center, Neurology Unit, University Hospital “Tor Vergata”, 00133 Rome, ItalyOtolaryngology Department, Silvestri University Hospital, University of Perugia, 06151 Perugia, ItalyAlthough several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.https://www.mdpi.com/2077-0383/10/21/5007migrainetransient-evoked otoacoustic emissionsdistortion-product otoacoustic emissionscochlear damagehearing impairmentolivocochlear system |
| spellingShingle | Maria Albanese Stefano Di Girolamo Lorenzo Silvani Eleonora Ciaschi Barbara Chiaramonte Matteo Conti Francesco Maria Passali Battista Di Gioia Nicola Biagio Mercuri Arianna Di Stadio Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study Journal of Clinical Medicine migraine transient-evoked otoacoustic emissions distortion-product otoacoustic emissions cochlear damage hearing impairment olivocochlear system |
| title | Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study |
| title_full | Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study |
| title_fullStr | Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study |
| title_full_unstemmed | Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study |
| title_short | Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study |
| title_sort | distortion product otoacoustic emissions and their suppression as predictors of peripheral auditory damage in migraine a case control study |
| topic | migraine transient-evoked otoacoustic emissions distortion-product otoacoustic emissions cochlear damage hearing impairment olivocochlear system |
| url | https://www.mdpi.com/2077-0383/10/21/5007 |
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