Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, w...

Full description

Bibliographic Details
Main Authors:	Ajay Bhargava, Steven Pelech, Ben Woodard, John Kerwin, Nimet Maherali, Reproducibility Project: Cancer Biology
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-02-01
Series:	eLife
Subjects:	methodology Reproducibility Project: Cancer Biology paradoxical activation BRAF inhibitors
Online Access:	https://elifesciences.org/articles/09976

Similar Items

Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
by: David Blum, et al.
Published: (2014-12-01)

Registered report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
by: Vidhu Sharma, et al.
Published: (2016-03-01)

Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
by: John Repass, et al.
Published: (2016-02-01)

Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
by: Denise Chroscinski, et al.
Published: (2015-02-01)

Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
by: Denise Chroscinski, et al.
Published: (2015-01-01)

Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
by: Ajay Bhargava, et al.
Published: (2016-02-01)

Registered report: Intestinal inflammation targets cancer-inducing activity of the microbiota
by: Kate Eaton, et al.
Published: (2015-03-01)

Registered report: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
by: Israr Khan, et al.
Published: (2015-09-01)

Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data
by: Irawati Kandela, et al.
Published: (2015-05-01)

Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
by: John Kerwin, et al.
Published: (2020-04-01)

Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
by: Brad Evans, et al.
Published: (2015-07-01)

Registered report: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
by: Irawati Kandela, et al.
Published: (2015-05-01)

Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
by: John Repass, et al.
Published: (2018-03-01)

BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors
by: Karisa C. Schreck, et al.
Published: (2019-08-01)

Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors
by: Edward Greenfield, et al.
Published: (2014-12-01)

RAF inhibitor re-challenge therapy in BRAF-aberrant pan-cancers: the RE-RAFFLE study
by: Blessie Elizabeth Nelson, et al.
Published: (2024-03-01)

V-raf murine sarcoma viral oncogene homolog B (BRAF) mutations in hairy cell leukaemia
by: Neeraj Arora, et al.
Published: (2015-01-01)

Registered report: Transcriptional amplification in tumor cells with elevated c-Myc
by: David Blum, et al.
Published: (2015-01-01)

Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations
by: Denise Chroscinski, et al.
Published: (2014-12-01)

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
by: Stephen K Horrigan, et al.
Published: (2017-01-01)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
by: Ufuk Degirmenci, et al.
Published: (2020-01-01)

Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
by: Jia Li, et al.
Published: (2015-07-01)

Prevalence and patterns of mutations in RAS/RAF/MEK/ERK/MAPK signaling pathway in colorectal cancer in North Africa
by: Meryem Jafari, et al.
Published: (2022-11-01)

Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data
by: Irawati Kandela, et al.
Published: (2017-01-01)

Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
by: Mitch Phelps, et al.
Published: (2016-03-01)

Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc
by: Irawati Kandela, et al.
Published: (2015-06-01)

Molecular Modeling Unveils the Effective Interaction of B-RAF Inhibitors with Rare B-RAF Insertion Variants
by: Maria Chiara Scaini, et al.
Published: (2023-07-01)

NRAS-driven melanoma: A RAF can hide another
by: Sabine Druillennec, et al.
Published: (2017-11-01)

Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
by: Samrrah Raouf, et al.
Published: (2015-01-01)

Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells
by: John P Vanden Heuvel, et al.
Published: (2016-06-01)

Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota
by: Kathryn Eaton, et al.
Published: (2018-10-01)

Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc
by: Fraser Aird, et al.
Published: (2017-01-01)

Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers
by: Vidhu Sharma, et al.
Published: (2016-02-01)

Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
by: Christine Mantis, et al.
Published: (2017-01-01)

Combination therapies to inhibit the RAF/MEK/ERK pathway in melanoma: we are not done yet.
by: Grant A. McArthur
Published: (2015-07-01)

Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
by: Babette Haven, et al.
Published: (2016-02-01)

Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia
by: Juan José Fung, et al.
Published: (2015-09-01)

Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
by: Steven Fiering, et al.
Published: (2015-07-01)

Registered report: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
by: Jake Lesnik, et al.
Published: (2016-01-01)

Registered report: Interactions between cancer stem cells and their niche govern metastatic colonization
by: Francesca Incardona, et al.
Published: (2015-06-01)