Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release
Agarose/succinoglycan hydrogels were prepared as pH-responsive drug delivery systems with significantly improved flexibility, thermostability, and porosity compared to agarose gels alone. Agarose/succinoglycan hydrogels were made using agarose and succinoglycan, a polysaccharide directly isolated fr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/13/2049 |
| _version_ | 1797529157600542720 |
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| author | Yiluo Hu Yohan Kim Inki Hong Moosung Kim Seunho Jung |
| author_facet | Yiluo Hu Yohan Kim Inki Hong Moosung Kim Seunho Jung |
| author_sort | Yiluo Hu |
| collection | DOAJ |
| description | Agarose/succinoglycan hydrogels were prepared as pH-responsive drug delivery systems with significantly improved flexibility, thermostability, and porosity compared to agarose gels alone. Agarose/succinoglycan hydrogels were made using agarose and succinoglycan, a polysaccharide directly isolated from <i>Sinorhizobium meliloti</i>. Mechanical and physical properties of agarose/succinoglycan hydrogels were investigated using various instrumental methods such as rheological measurements, attenuated total reflection–Fourier transform infrared (ATR-FTIR) spectroscopic analysis, X-ray diffraction (XRD), and field-emission scanning electron microscopy (FE-SEM). The results showed that the agarose/succinoglycan hydrogels became flexible and stable network gels with an improved swelling pattern in basic solution compared to the hard and brittle agarose gel alone. In addition, these hydrogels showed a pH-responsive delivery of ciprofloxacin (CPFX), with a cumulative release of ~41% within 35 h at pH 1.2 and complete release at pH 7.4. Agarose/succinoglycan hydrogels also proved to be non-toxic as a result of the cell cytotoxicity test, suggesting that these hydrogels would be a potential natural biomaterial for biomedical applications such as various drug delivery system and cell culture scaffolds. |
| first_indexed | 2024-03-10T10:09:45Z |
| format | Article |
| id | doaj.art-6dc5dda4ce27472db2833f8c693625a6 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T10:09:45Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-6dc5dda4ce27472db2833f8c693625a62023-11-22T01:17:19ZengMDPI AGPolymers2073-43602021-06-011313204910.3390/polym13132049Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug ReleaseYiluo Hu0Yohan Kim1Inki Hong2Moosung Kim3Seunho Jung4Center for Biotechnology Research in UBITA (CBRU), Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, KoreaCenter for Biotechnology Research in UBITA (CBRU), Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, KoreaCovergence Technology Laboratory, Kolmar Korea, 61, Heolleung-ro-8-gil, Seocho-gu, Seoul 05029, KoreaMacrocare, 32 Gangni 1-gil, Cheongju 28126, KoreaCenter for Biotechnology Research in UBITA (CBRU), Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, KoreaAgarose/succinoglycan hydrogels were prepared as pH-responsive drug delivery systems with significantly improved flexibility, thermostability, and porosity compared to agarose gels alone. Agarose/succinoglycan hydrogels were made using agarose and succinoglycan, a polysaccharide directly isolated from <i>Sinorhizobium meliloti</i>. Mechanical and physical properties of agarose/succinoglycan hydrogels were investigated using various instrumental methods such as rheological measurements, attenuated total reflection–Fourier transform infrared (ATR-FTIR) spectroscopic analysis, X-ray diffraction (XRD), and field-emission scanning electron microscopy (FE-SEM). The results showed that the agarose/succinoglycan hydrogels became flexible and stable network gels with an improved swelling pattern in basic solution compared to the hard and brittle agarose gel alone. In addition, these hydrogels showed a pH-responsive delivery of ciprofloxacin (CPFX), with a cumulative release of ~41% within 35 h at pH 1.2 and complete release at pH 7.4. Agarose/succinoglycan hydrogels also proved to be non-toxic as a result of the cell cytotoxicity test, suggesting that these hydrogels would be a potential natural biomaterial for biomedical applications such as various drug delivery system and cell culture scaffolds.https://www.mdpi.com/2073-4360/13/13/2049hydrogelsagarosesuccinoglycandrug deliverypH-responsive |
| spellingShingle | Yiluo Hu Yohan Kim Inki Hong Moosung Kim Seunho Jung Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release Polymers hydrogels agarose succinoglycan drug delivery pH-responsive |
| title | Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release |
| title_full | Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release |
| title_fullStr | Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release |
| title_full_unstemmed | Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release |
| title_short | Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release |
| title_sort | fabrication of flexible ph responsive agarose succinoglycan hydrogels for controlled drug release |
| topic | hydrogels agarose succinoglycan drug delivery pH-responsive |
| url | https://www.mdpi.com/2073-4360/13/13/2049 |
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