Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series
Abstract Background To explore the efficacy of follitropin delta in ovarian stimulation of patients with the Rotterdam ESHRE/ASRM 2003 phenotypes of polycystic ovarian syndrome (PCOS) using a retrospective case series with an electronic file search in a reproductive medicine clinic. Case presentatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00773-5 |
| _version_ | 1828080467271745536 |
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| author | Stephanie Yacoub Kenneth Cadesky Robert F. Casper |
| author_facet | Stephanie Yacoub Kenneth Cadesky Robert F. Casper |
| author_sort | Stephanie Yacoub |
| collection | DOAJ |
| description | Abstract Background To explore the efficacy of follitropin delta in ovarian stimulation of patients with the Rotterdam ESHRE/ASRM 2003 phenotypes of polycystic ovarian syndrome (PCOS) using a retrospective case series with an electronic file search in a reproductive medicine clinic. Case presentation Seventy-four patients with PCOS undergoing ovarian stimulation according to the individualized dosing algorithm of follitropin delta for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI)/oocyte freezing were included. Follitropin delta resulted in a high number of pre-ovulatory follicles at the end of stimulation as expected in patients with PCOS. There was a large number of oocytes retrieved with an acceptable percentage of metaphase II (MII) oocytes. There were no cases of moderate or severe OHSS across all phenotypes. Conclusion Follitropin delta, using the individualized dosing algorithm, appears to be a safe method of ovarian stimulation with a low risk of OHSS in PCOS patients without sacrificing successful stimulation outcomes. |
| first_indexed | 2024-04-11T03:19:22Z |
| format | Article |
| id | doaj.art-6dc695debae841eebda08574c6992a5f |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:19:22Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-6dc695debae841eebda08574c6992a5f2023-01-02T09:32:29ZengBMCJournal of Ovarian Research1757-22152021-02-011411610.1186/s13048-021-00773-5Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case seriesStephanie Yacoub0Kenneth Cadesky1Robert F. Casper2Present address: Department of Obstetrics and Gynecology, Saint Georges Hospital University Medical CenterTRIO Fertility, and Department of Obstetrics and Gynecology, University of TorontoTRIO Fertility, and Department of Obstetrics and Gynecology, University of TorontoAbstract Background To explore the efficacy of follitropin delta in ovarian stimulation of patients with the Rotterdam ESHRE/ASRM 2003 phenotypes of polycystic ovarian syndrome (PCOS) using a retrospective case series with an electronic file search in a reproductive medicine clinic. Case presentation Seventy-four patients with PCOS undergoing ovarian stimulation according to the individualized dosing algorithm of follitropin delta for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI)/oocyte freezing were included. Follitropin delta resulted in a high number of pre-ovulatory follicles at the end of stimulation as expected in patients with PCOS. There was a large number of oocytes retrieved with an acceptable percentage of metaphase II (MII) oocytes. There were no cases of moderate or severe OHSS across all phenotypes. Conclusion Follitropin delta, using the individualized dosing algorithm, appears to be a safe method of ovarian stimulation with a low risk of OHSS in PCOS patients without sacrificing successful stimulation outcomes.https://doi.org/10.1186/s13048-021-00773-5Polycystic ovary syndromeRotterdam criteriaFollitropin deltaRecombinant FSHOHSS |
| spellingShingle | Stephanie Yacoub Kenneth Cadesky Robert F. Casper Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series Journal of Ovarian Research Polycystic ovary syndrome Rotterdam criteria Follitropin delta Recombinant FSH OHSS |
| title | Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series |
| title_full | Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series |
| title_fullStr | Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series |
| title_full_unstemmed | Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series |
| title_short | Low risk of OHSS with follitropin delta use in women with different polycystic ovary syndrome phenotypes: a retrospective case series |
| title_sort | low risk of ohss with follitropin delta use in women with different polycystic ovary syndrome phenotypes a retrospective case series |
| topic | Polycystic ovary syndrome Rotterdam criteria Follitropin delta Recombinant FSH OHSS |
| url | https://doi.org/10.1186/s13048-021-00773-5 |
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