DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication

Emerging studies reveal that neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are commonly linked to DNA damage accumulation and repair deficiency. Neurons are particularly vulnerable to DNA damage due to their high metabolic activity, rel...

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Bibliographic Details
Main Authors: Haibo Wang, Manohar Kodavati, Gavin W. Britz, Muralidhar L. Hegde
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyotrophic lateral sclerosis
frontotemporal dementia
FUS
DNA damage
DNA repair deficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.784361/full

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