Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria
Abstract Background and Aims Potentially inappropriate medications (PIMs) carry risks that outweigh any potential benefits when compared to safer or more effective alternative treatments. Adverse drug events are more likely to occur in older adults with psychiatric diseases due to multimorbidity, po...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1247 |
| _version_ | 1827938716624093184 |
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| author | Gracia Yaghi Bahia Chahine |
| author_facet | Gracia Yaghi Bahia Chahine |
| author_sort | Gracia Yaghi |
| collection | DOAJ |
| description | Abstract Background and Aims Potentially inappropriate medications (PIMs) carry risks that outweigh any potential benefits when compared to safer or more effective alternative treatments. Adverse drug events are more likely to occur in older adults with psychiatric diseases due to multimorbidity, polypharmacy, and age‐related changes in drug pharmacokinetics and pharmacodynamics. The aim of this study was to assess the prevalence and risk factors of PIM use in an aged care hospital's psychogeriatric division, using the American Geriatrics Society Beers criteria 2019. Methods This cross‐sectional study was conducted on all current inpatients, having a mental disorder and aged ≥65 years, in one elderly care hospital in Beirut, from March to May 2022. Medications, sociodemographic and clinical characteristics were collected from patients' medical records. PIMs were evaluated based on Beers criteria 2019. Independent variables were described using descriptive statistics. Factors associated with PIM use were identified by bivariate analysis followed by binary logistic regression. A two‐sided p value <0.05 was considered statistically significant. Results The study included 147 patients, with a mean age of 76.3 years, 46.9% of them having schizophrenia, 68.7% using 5 or more drugs and 90.5% taking at least 1 PIM. The most prescribed PIMs were antipsychotics (40.2%), anticholinergics (16%), and antidepressants (7.8%). PIM use was significantly associated with polypharmacy (AOR = 20.88, 95% CI: 1.22−357.87, p = 0.04) and anticholinergic cognitive burden (ACB) score (AOR = 7.25, 95% CI: 1.13−46.52, p = 0.04). Conclusion PIMs were highly prevalent among hospitalized Lebanese psychiatric elderly. Polypharmacy and ACB score were the determinants of PIM use. A multidisciplinary medication review led by a clinical pharmacist could reduce PIM use. |
| first_indexed | 2024-03-13T08:42:02Z |
| format | Article |
| id | doaj.art-6dca845706f448348d21e3dcbf71be96 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-13T08:42:02Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-6dca845706f448348d21e3dcbf71be962023-05-30T08:58:34ZengWileyHealth Science Reports2398-88352023-05-0165n/an/a10.1002/hsr2.1247Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteriaGracia Yaghi0Bahia Chahine1School of Pharmacy Lebanese International University Beirut LebanonSchool of Pharmacy Lebanese International University Beirut LebanonAbstract Background and Aims Potentially inappropriate medications (PIMs) carry risks that outweigh any potential benefits when compared to safer or more effective alternative treatments. Adverse drug events are more likely to occur in older adults with psychiatric diseases due to multimorbidity, polypharmacy, and age‐related changes in drug pharmacokinetics and pharmacodynamics. The aim of this study was to assess the prevalence and risk factors of PIM use in an aged care hospital's psychogeriatric division, using the American Geriatrics Society Beers criteria 2019. Methods This cross‐sectional study was conducted on all current inpatients, having a mental disorder and aged ≥65 years, in one elderly care hospital in Beirut, from March to May 2022. Medications, sociodemographic and clinical characteristics were collected from patients' medical records. PIMs were evaluated based on Beers criteria 2019. Independent variables were described using descriptive statistics. Factors associated with PIM use were identified by bivariate analysis followed by binary logistic regression. A two‐sided p value <0.05 was considered statistically significant. Results The study included 147 patients, with a mean age of 76.3 years, 46.9% of them having schizophrenia, 68.7% using 5 or more drugs and 90.5% taking at least 1 PIM. The most prescribed PIMs were antipsychotics (40.2%), anticholinergics (16%), and antidepressants (7.8%). PIM use was significantly associated with polypharmacy (AOR = 20.88, 95% CI: 1.22−357.87, p = 0.04) and anticholinergic cognitive burden (ACB) score (AOR = 7.25, 95% CI: 1.13−46.52, p = 0.04). Conclusion PIMs were highly prevalent among hospitalized Lebanese psychiatric elderly. Polypharmacy and ACB score were the determinants of PIM use. A multidisciplinary medication review led by a clinical pharmacist could reduce PIM use.https://doi.org/10.1002/hsr2.1247Beers criteriaLebanonolder adultspolypharmacypotentially inappropriate medicationpsychiatric disorders |
| spellingShingle | Gracia Yaghi Bahia Chahine Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria Health Science Reports Beers criteria Lebanon older adults polypharmacy potentially inappropriate medication psychiatric disorders |
| title | Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria |
| title_full | Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria |
| title_fullStr | Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria |
| title_full_unstemmed | Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria |
| title_short | Potentially inappropriate medications use in a psychiatric elderly care hospital: A cross‐sectional study using Beers criteria |
| title_sort | potentially inappropriate medications use in a psychiatric elderly care hospital a cross sectional study using beers criteria |
| topic | Beers criteria Lebanon older adults polypharmacy potentially inappropriate medication psychiatric disorders |
| url | https://doi.org/10.1002/hsr2.1247 |
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