Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases
The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different human body sites, including the gut, oral cavity, skin, and eyes. In particular, the presence of an ocular surface microbiota with a crucial role in maintaining ocular surface homeo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13338 |
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| author | Lucrezia Irene Maria Campagnoli Angelica Varesi Annalisa Barbieri Nicoletta Marchesi Alessia Pascale |
| author_facet | Lucrezia Irene Maria Campagnoli Angelica Varesi Annalisa Barbieri Nicoletta Marchesi Alessia Pascale |
| author_sort | Lucrezia Irene Maria Campagnoli |
| collection | DOAJ |
| description | The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different human body sites, including the gut, oral cavity, skin, and eyes. In particular, the presence of an ocular surface microbiota with a crucial role in maintaining ocular surface homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline a potential association between gut microbiota (GM) and ocular health. In this respect, some evidence supports the existence of a gut–eye axis involved in the pathogenesis of several ocular diseases, including age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, and glaucoma. Therefore, understanding the link between the GM and these ocular disorders might be useful for the development of new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal microbiota transplantation through which the GM could be modulated, thus allowing better management of these diseases. |
| first_indexed | 2024-03-10T23:21:26Z |
| format | Article |
| id | doaj.art-6dca9bfd45f2437f98b80778737cba4a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:21:26Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6dca9bfd45f2437f98b80778737cba4a2023-11-19T08:15:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171333810.3390/ijms241713338Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular DiseasesLucrezia Irene Maria Campagnoli0Angelica Varesi1Annalisa Barbieri2Nicoletta Marchesi3Alessia Pascale4Department of Drug Sciences, Unit of Pharmacology, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology, University of Pavia, 27100 Pavia, ItalyDepartment of Drug Sciences, Unit of Pharmacology, University of Pavia, 27100 Pavia, ItalyDepartment of Drug Sciences, Unit of Pharmacology, University of Pavia, 27100 Pavia, ItalyDepartment of Drug Sciences, Unit of Pharmacology, University of Pavia, 27100 Pavia, ItalyThe human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different human body sites, including the gut, oral cavity, skin, and eyes. In particular, the presence of an ocular surface microbiota with a crucial role in maintaining ocular surface homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline a potential association between gut microbiota (GM) and ocular health. In this respect, some evidence supports the existence of a gut–eye axis involved in the pathogenesis of several ocular diseases, including age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, and glaucoma. Therefore, understanding the link between the GM and these ocular disorders might be useful for the development of new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal microbiota transplantation through which the GM could be modulated, thus allowing better management of these diseases.https://www.mdpi.com/1422-0067/24/17/13338ocular microbiotagut–eye axisgut microbiotaage-related macular degenerationuveitisdiabetic retinopathy |
| spellingShingle | Lucrezia Irene Maria Campagnoli Angelica Varesi Annalisa Barbieri Nicoletta Marchesi Alessia Pascale Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases International Journal of Molecular Sciences ocular microbiota gut–eye axis gut microbiota age-related macular degeneration uveitis diabetic retinopathy |
| title | Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases |
| title_full | Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases |
| title_fullStr | Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases |
| title_full_unstemmed | Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases |
| title_short | Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases |
| title_sort | targeting the gut eye axis an emerging strategy to face ocular diseases |
| topic | ocular microbiota gut–eye axis gut microbiota age-related macular degeneration uveitis diabetic retinopathy |
| url | https://www.mdpi.com/1422-0067/24/17/13338 |
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