Synthesis, characterization, molecular docking, in silico ADME study, and in vitro cytotoxicity evaluation of new pyridine derivatives of nabumetone.

Synthesis, characterization, molecular docking, in silico ADME study, and in vitro cytotoxicity evaluation of new pyridine derivatives of nabumetone.

New pyridine derivatives of nabumetone containing 2-amino 3-cyano moieties were synthesized and aimed to introduce new EGFR kinase inhibitors through two methods either by synthesis of chalcone derivatives initially (1a-d) followed by reacting it with malononitrile and ammonium acetate to form (...

Full description

Bibliographic Details
Main Authors:	Bushra K. Jameel, Ayad Mohammed Rasheed Raauf, Wassan Abdul Kareem Abbas
Format:	Article
Language:	English
Published:	College of Pharmacy / Mustansiriyah University 2023-07-01
Series:	Al-Mustansiriyah Journal of Pharmaceutical Sciences
Subjects:	Nabumetone, EGFR inhibitor, cyanopyridine, anticancer, molecular docking
Online Access:	https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1042

Similar Items

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone
by: Ayad M. R Raauf, et al.
Published: (2019-08-01)

Molecular Docking study, and In vitro Evaluation of Antitumor Activity of Some New Isoxazoline and Pyrazoline Derivatives of Nabumetone against breast cancer cell line (MCF-7)
by: Kanar Muthanna Alawad, et al.
Published: (2022-10-01)

Effect of nabumetone on humoral immune responses in mice
by: Khalid Naveed, et al.
Published: (2020-07-01)

Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having
by: Duha E. Taha, et al.
Published: (2019-12-01)

Gel Formulation of Nabumetone and a Newly Synthesized Analog: Microemulsion as a Photoprotective Topical Delivery System
by: Fedora Grande, et al.
Published: (2020-05-01)

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
by: M.S. Raghu, et al.
Published: (2023-09-01)

Synthesis and in-silico studies of 4-(5-(2-(4-(5-aryl-1,2,4-thiadiazol-3-yl)phenyl)-1H-imidazol-4-yl)-1,3,4-thiadiazol-2-yl)pyridines
by: Shashikala Kethireddy, et al.
Published: (2024-01-01)

Synthesis, anti-inflammatory, molecular docking and ADME studies of new derivatives of ketoprofen as cyclooxygenases inhibitor
by: Mustafa M. Allawi, et al.
Published: (2019-12-01)

Discovery of Novel 3-Cyanopyridines as Survivin Modulators and Apoptosis Inducers
by: Rehab Sabour, et al.
Published: (2020-10-01)

Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
by: Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
Published: (2015-12-01)

Synthesis, anticancer activity and docking studies of pyrazoline and pyrimidine derivatives as potential epidermal growth factor receptor (EGFR) inhibitors
by: Menier Al-Anazi, et al.
Published: (2022-07-01)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors
by: Tarfah Al-Warhi, et al.
Published: (2023-12-01)

Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin
by: Elwira Chrobak, et al.
Published: (2021-01-01)

Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects
by: Fedora Grande, et al.
Published: (2021-06-01)

Synthesis, crystal structure and properties of tetrakis(pyridine-3-carbonitrile)dithiocyanatoiron(II) and of diaquabis(pyridine-3-carbonitrile)dithiocyanatoiron(II) pyridine-3-carbonitrile monosolvate
by: Christian Näther, et al.
Published: (2023-11-01)

5-Acetyl-2-{[(1H-benzimidazol-2-yl)methyl]sulfanyl}-4-(4-methoxyphenyl)-6-methylpyridine-3-carbonitrile
by: Joel T. Mague, et al.
Published: (2016-04-01)

Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers
by: Mostafa M. Ghorab, et al.
Published: (2021-01-01)

New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study
by: Marwa I. Serag, et al.
Published: (2024-03-01)

4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
by: Deepika Sharma, et al.
Published: (2019-04-01)

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>: Design, Synthesis, and Antiproliferative Activity
by: Lamya H. Al-Wahaibi, et al.
Published: (2023-10-01)

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
by: Reham R. Khattab, et al.
Published: (2021-01-01)

In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers
by: Fahad Alminderej, et al.
Published: (2023-07-01)

Design and Synthesis of New Hydantoin Acetanilide Derivatives as Anti-NSCLC Targeting EGFR<sup>L858R/T790M</sup> Mutations
by: Moamen A. Hassanin, et al.
Published: (2022-07-01)

Novel 7-Chloro-4-aminoquinoline-benzimidazole Hybrids as Inhibitors of Cancer Cells Growth: Synthesis, Antiproliferative Activity, in Silico ADME Predictions, and Docking
by: Luka Krstulović, et al.
Published: (2023-01-01)

New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells
by: Ahmed Malki, et al.
Published: (2016-02-01)

Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles
by: Arnika Das, et al.
Published: (2021-01-01)

Synthesis, in silico molecular docking analysis, pharmacokinetic properties and evaluation of antibacterial and antioxidant activities of fluoroquinolines
by: Mona Fekadu, et al.
Published: (2022-01-01)

Synthesis and Characterization of Some New Pyridine and Pyrimidine Derivatives and Studying Their Biological Activities
by: Israa R. A. Al-Hussein, et al.
Published: (2023-06-01)

New Anticancer Theobromine Derivative Targeting EGFR<sup>WT</sup> and EGFR<sup>T790M</sup>: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
by: Eslam B. Elkaeed, et al.
Published: (2022-09-01)

Synthesis, Cytotoxicity Evaluation and Molecular Docking Studyof <i>N</i>-Phenylpyrazoline Derivatives
by: Artania Adnin Tri Suma, et al.
Published: (2019-08-01)

Synthesis, Cytotoxic Activity and Docking Study of Two Indole-Chalcone Derivatives
by: Hassan Mirzaei, et al.
Published: (2017-11-01)

Novel Perbutyrylated Glucose Derivatives of (–)-Epigallocatechin-3-Gallate Inhibit Cancer Cells Proliferation by Decreasing Phosphorylation of the EGFR: Synthesis, Cytotoxicity, and Molecular Docking
by: Ya Wang, et al.
Published: (2021-07-01)

Synthesis, In Vitro Evaluation and Molecular Docking Studies of Novel Thiophenyl Thiazolyl-Pyridine Hybrids as Potential Anticancer Agents
by: Fayza O. Ashmawy, et al.
Published: (2023-05-01)

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile
by: Ayesha Naseer, et al.
Published: (2022-10-01)

A microwave-assisted facile synthesis of novel coumarin derivatives containing cyanopyridine and furan as antimicrobial agents
by: N.C. Desai, et al.
Published: (2017-01-01)

Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway
by: Xu L, et al.
Published: (2019-09-01)

Thiazolopyrimidine as a Promising Anticancer Pharmacophore: In Silico Drug Design, Molecular Docking and ADMET Prediction Studies
by: Omar A. El-Khouly, et al.
Published: (2022-11-01)

Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
by: Mohamed Alswah, et al.
Published: (2017-12-01)

Novel Benzimidazole-Based Compounds as Antimicrobials: Synthesis, Molecular Docking, Molecular Dynamics and in silico ADME Profile Studies
by: Elif Yeşilçayır, et al.
Published: (2022-06-01)

Kinase Inhibitory Activities and Molecular Docking of a Novel Series of Anticancer Pyrazole Derivatives
by: Eman S. Nossier, et al.
Published: (2018-11-01)