Invariant natural killer T cells in lung diseases
Abstract Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens. These cells are found in all tissues, and evidence to date suggests that they play many immunologica...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-09-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01024-x |
| _version_ | 1827797075916488704 |
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| author | Dongjin Jeong Yeon Duk Woo Doo Hyun Chung |
| author_facet | Dongjin Jeong Yeon Duk Woo Doo Hyun Chung |
| author_sort | Dongjin Jeong |
| collection | DOAJ |
| description | Abstract Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens. These cells are found in all tissues, and evidence to date suggests that they play many immunological roles in both homeostasis and inflammatory conditions. The latter include lung inflammatory diseases such as asthma and infections: the roles of lung-resident iNKT cells in these diseases have been extensively researched. Here, we provide insights into the biology of iNKT cells in health and disease, with a particular focus on the role of pulmonary iNKT cells in airway inflammation and other lung diseases. |
| first_indexed | 2024-03-11T19:17:07Z |
| format | Article |
| id | doaj.art-6dce0bdf465a4f1497113e6bf912357f |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-11T19:17:07Z |
| publishDate | 2023-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-6dce0bdf465a4f1497113e6bf912357f2023-10-08T11:07:49ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-09-015591885189410.1038/s12276-023-01024-xInvariant natural killer T cells in lung diseasesDongjin Jeong0Yeon Duk Woo1Doo Hyun Chung2Laboratory of Immune Regulation in Department of Biomedical Sciences, Seoul National University College of MedicineLaboratory of Immune Regulation in Department of Biomedical Sciences, Seoul National University College of MedicineLaboratory of Immune Regulation in Department of Biomedical Sciences, Seoul National University College of MedicineAbstract Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens. These cells are found in all tissues, and evidence to date suggests that they play many immunological roles in both homeostasis and inflammatory conditions. The latter include lung inflammatory diseases such as asthma and infections: the roles of lung-resident iNKT cells in these diseases have been extensively researched. Here, we provide insights into the biology of iNKT cells in health and disease, with a particular focus on the role of pulmonary iNKT cells in airway inflammation and other lung diseases.https://doi.org/10.1038/s12276-023-01024-x |
| spellingShingle | Dongjin Jeong Yeon Duk Woo Doo Hyun Chung Invariant natural killer T cells in lung diseases Experimental and Molecular Medicine |
| title | Invariant natural killer T cells in lung diseases |
| title_full | Invariant natural killer T cells in lung diseases |
| title_fullStr | Invariant natural killer T cells in lung diseases |
| title_full_unstemmed | Invariant natural killer T cells in lung diseases |
| title_short | Invariant natural killer T cells in lung diseases |
| title_sort | invariant natural killer t cells in lung diseases |
| url | https://doi.org/10.1038/s12276-023-01024-x |
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