Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients

BACKGROUND: Asthma is a multifaceted condition defined by chronic airway inflammation. Skin prick test (SPT), serum total immunoglobulin E (tIgE), and absolute eosinophil counts (AEC) estimation are commonly available tools for evaluating allergen sensitization. OBJECTIVE: The present study evalua...

Full description

Bibliographic Details
Main Authors: Manoj Kumar, Rajesh Kumar Gupta, Anil Kumar Mavi, Kamal Singh, Raj Kumar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Indian Journal of Allergy Asthma and Immunology
Subjects:
Online Access:http://www.ijaai.in/article.asp?issn=0972-6691;year=2022;volume=36;issue=1;spage=54;epage=59;aulast=Kumar
_version_ 1797775219589382144
author Manoj Kumar
Rajesh Kumar Gupta
Anil Kumar Mavi
Kamal Singh
Raj Kumar
author_facet Manoj Kumar
Rajesh Kumar Gupta
Anil Kumar Mavi
Kamal Singh
Raj Kumar
author_sort Manoj Kumar
collection DOAJ
description BACKGROUND: Asthma is a multifaceted condition defined by chronic airway inflammation. Skin prick test (SPT), serum total immunoglobulin E (tIgE), and absolute eosinophil counts (AEC) estimation are commonly available tools for evaluating allergen sensitization. OBJECTIVE: The present study evaluates the sensitivity to common aeroallergens and also compares serum tIgE and AEC levels with spirometry in Indian individuals with a history of allergy symptoms. MATERIALS AND METHODS: An observational prospective study was conducted in the Outpatient Department of Viswanathan Chest Hospital, VPCI, Delhi, between 2017 and 2019. Two hundred asthma patients diagnosed as per the Global Initiative for Asthma guidelines undergo SPT against a battery of common aeroallergens and measured serum tIgE and AEC. RESULTS: Out of 200 cases, the overall prevalence of common aeroallergens sensitization was found to be 57% (114) in asthmatic patients (atopic). SPT positivity to common aeroallergens was highest in people between the ages of 21 and 30 and lowest in people over 50. The most prevalent annoying aeroallergens were found to be weed pollens (14%), house dust mites (11%), fungi (10.5%), tree pollen (9.5%), dust (6%), kapok cotton (5.5%), grass pollen (3.5%), silk (1.5%), and wool (1%). The mean tIgE was higher in atopic asthmatic patients than in nonatopic asthmatic patients (553.25 ± 218.12 IU/ml and 489.1 ± 251.16 IU/ml; P = 0.056). CONCLUSION: In the present study, we found that insects are the most common offending aeroallergens with higher SPT sensitivity and serum tIgE in atopic patients. Spirometry severity is not affected by allergens sensitivity in asthma patients.
first_indexed 2024-03-12T22:32:35Z
format Article
id doaj.art-6dcffea36521402aa1ee98a0815bde4f
institution Directory Open Access Journal
issn 0972-6691
language English
last_indexed 2024-03-12T22:32:35Z
publishDate 2022-01-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Indian Journal of Allergy Asthma and Immunology
spelling doaj.art-6dcffea36521402aa1ee98a0815bde4f2023-07-21T14:45:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Allergy Asthma and Immunology0972-66912022-01-01361545910.4103/ijaai.ijaai_1_23Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patientsManoj KumarRajesh Kumar GuptaAnil Kumar MaviKamal SinghRaj KumarBACKGROUND: Asthma is a multifaceted condition defined by chronic airway inflammation. Skin prick test (SPT), serum total immunoglobulin E (tIgE), and absolute eosinophil counts (AEC) estimation are commonly available tools for evaluating allergen sensitization. OBJECTIVE: The present study evaluates the sensitivity to common aeroallergens and also compares serum tIgE and AEC levels with spirometry in Indian individuals with a history of allergy symptoms. MATERIALS AND METHODS: An observational prospective study was conducted in the Outpatient Department of Viswanathan Chest Hospital, VPCI, Delhi, between 2017 and 2019. Two hundred asthma patients diagnosed as per the Global Initiative for Asthma guidelines undergo SPT against a battery of common aeroallergens and measured serum tIgE and AEC. RESULTS: Out of 200 cases, the overall prevalence of common aeroallergens sensitization was found to be 57% (114) in asthmatic patients (atopic). SPT positivity to common aeroallergens was highest in people between the ages of 21 and 30 and lowest in people over 50. The most prevalent annoying aeroallergens were found to be weed pollens (14%), house dust mites (11%), fungi (10.5%), tree pollen (9.5%), dust (6%), kapok cotton (5.5%), grass pollen (3.5%), silk (1.5%), and wool (1%). The mean tIgE was higher in atopic asthmatic patients than in nonatopic asthmatic patients (553.25 ± 218.12 IU/ml and 489.1 ± 251.16 IU/ml; P = 0.056). CONCLUSION: In the present study, we found that insects are the most common offending aeroallergens with higher SPT sensitivity and serum tIgE in atopic patients. Spirometry severity is not affected by allergens sensitivity in asthma patients.http://www.ijaai.in/article.asp?issn=0972-6691;year=2022;volume=36;issue=1;spage=54;epage=59;aulast=Kumarasthmacockroachskin prick testspirometrytotal immunoglobulin e
spellingShingle Manoj Kumar
Rajesh Kumar Gupta
Anil Kumar Mavi
Kamal Singh
Raj Kumar
Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
Indian Journal of Allergy Asthma and Immunology
asthma
cockroach
skin prick test
spirometry
total immunoglobulin e
title Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
title_full Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
title_fullStr Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
title_full_unstemmed Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
title_short Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
title_sort relevance of skin prick test serum total immunoglobulin e and absolute eosinophil counts in asthma patients
topic asthma
cockroach
skin prick test
spirometry
total immunoglobulin e
url http://www.ijaai.in/article.asp?issn=0972-6691;year=2022;volume=36;issue=1;spage=54;epage=59;aulast=Kumar
work_keys_str_mv AT manojkumar relevanceofskinpricktestserumtotalimmunoglobulineandabsoluteeosinophilcountsinasthmapatients
AT rajeshkumargupta relevanceofskinpricktestserumtotalimmunoglobulineandabsoluteeosinophilcountsinasthmapatients
AT anilkumarmavi relevanceofskinpricktestserumtotalimmunoglobulineandabsoluteeosinophilcountsinasthmapatients
AT kamalsingh relevanceofskinpricktestserumtotalimmunoglobulineandabsoluteeosinophilcountsinasthmapatients
AT rajkumar relevanceofskinpricktestserumtotalimmunoglobulineandabsoluteeosinophilcountsinasthmapatients