Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients
BACKGROUND: Asthma is a multifaceted condition defined by chronic airway inflammation. Skin prick test (SPT), serum total immunoglobulin E (tIgE), and absolute eosinophil counts (AEC) estimation are commonly available tools for evaluating allergen sensitization. OBJECTIVE: The present study evalua...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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Series: | Indian Journal of Allergy Asthma and Immunology |
Subjects: | |
Online Access: | http://www.ijaai.in/article.asp?issn=0972-6691;year=2022;volume=36;issue=1;spage=54;epage=59;aulast=Kumar |
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author | Manoj Kumar Rajesh Kumar Gupta Anil Kumar Mavi Kamal Singh Raj Kumar |
author_facet | Manoj Kumar Rajesh Kumar Gupta Anil Kumar Mavi Kamal Singh Raj Kumar |
author_sort | Manoj Kumar |
collection | DOAJ |
description | BACKGROUND: Asthma is a multifaceted condition defined by chronic airway inflammation. Skin prick test (SPT), serum total immunoglobulin E (tIgE), and absolute eosinophil counts (AEC) estimation are commonly available tools for evaluating allergen sensitization.
OBJECTIVE: The present study evaluates the sensitivity to common aeroallergens and also compares serum tIgE and AEC levels with spirometry in Indian individuals with a history of allergy symptoms.
MATERIALS AND METHODS: An observational prospective study was conducted in the Outpatient Department of Viswanathan Chest Hospital, VPCI, Delhi, between 2017 and 2019. Two hundred asthma patients diagnosed as per the Global Initiative for Asthma guidelines undergo SPT against a battery of common aeroallergens and measured serum tIgE and AEC.
RESULTS: Out of 200 cases, the overall prevalence of common aeroallergens sensitization was found to be 57% (114) in asthmatic patients (atopic). SPT positivity to common aeroallergens was highest in people between the ages of 21 and 30 and lowest in people over 50. The most prevalent annoying aeroallergens were found to be weed pollens (14%), house dust mites (11%), fungi (10.5%), tree pollen (9.5%), dust (6%), kapok cotton (5.5%), grass pollen (3.5%), silk (1.5%), and wool (1%). The mean tIgE was higher in atopic asthmatic patients than in nonatopic asthmatic patients (553.25 ± 218.12 IU/ml and 489.1 ± 251.16 IU/ml; P = 0.056).
CONCLUSION: In the present study, we found that insects are the most common offending aeroallergens with higher SPT sensitivity and serum tIgE in atopic patients. Spirometry severity is not affected by allergens sensitivity in asthma patients. |
first_indexed | 2024-03-12T22:32:35Z |
format | Article |
id | doaj.art-6dcffea36521402aa1ee98a0815bde4f |
institution | Directory Open Access Journal |
issn | 0972-6691 |
language | English |
last_indexed | 2024-03-12T22:32:35Z |
publishDate | 2022-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Indian Journal of Allergy Asthma and Immunology |
spelling | doaj.art-6dcffea36521402aa1ee98a0815bde4f2023-07-21T14:45:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Allergy Asthma and Immunology0972-66912022-01-01361545910.4103/ijaai.ijaai_1_23Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patientsManoj KumarRajesh Kumar GuptaAnil Kumar MaviKamal SinghRaj KumarBACKGROUND: Asthma is a multifaceted condition defined by chronic airway inflammation. Skin prick test (SPT), serum total immunoglobulin E (tIgE), and absolute eosinophil counts (AEC) estimation are commonly available tools for evaluating allergen sensitization. OBJECTIVE: The present study evaluates the sensitivity to common aeroallergens and also compares serum tIgE and AEC levels with spirometry in Indian individuals with a history of allergy symptoms. MATERIALS AND METHODS: An observational prospective study was conducted in the Outpatient Department of Viswanathan Chest Hospital, VPCI, Delhi, between 2017 and 2019. Two hundred asthma patients diagnosed as per the Global Initiative for Asthma guidelines undergo SPT against a battery of common aeroallergens and measured serum tIgE and AEC. RESULTS: Out of 200 cases, the overall prevalence of common aeroallergens sensitization was found to be 57% (114) in asthmatic patients (atopic). SPT positivity to common aeroallergens was highest in people between the ages of 21 and 30 and lowest in people over 50. The most prevalent annoying aeroallergens were found to be weed pollens (14%), house dust mites (11%), fungi (10.5%), tree pollen (9.5%), dust (6%), kapok cotton (5.5%), grass pollen (3.5%), silk (1.5%), and wool (1%). The mean tIgE was higher in atopic asthmatic patients than in nonatopic asthmatic patients (553.25 ± 218.12 IU/ml and 489.1 ± 251.16 IU/ml; P = 0.056). CONCLUSION: In the present study, we found that insects are the most common offending aeroallergens with higher SPT sensitivity and serum tIgE in atopic patients. Spirometry severity is not affected by allergens sensitivity in asthma patients.http://www.ijaai.in/article.asp?issn=0972-6691;year=2022;volume=36;issue=1;spage=54;epage=59;aulast=Kumarasthmacockroachskin prick testspirometrytotal immunoglobulin e |
spellingShingle | Manoj Kumar Rajesh Kumar Gupta Anil Kumar Mavi Kamal Singh Raj Kumar Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients Indian Journal of Allergy Asthma and Immunology asthma cockroach skin prick test spirometry total immunoglobulin e |
title | Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients |
title_full | Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients |
title_fullStr | Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients |
title_full_unstemmed | Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients |
title_short | Relevance of skin prick test, serum total immunoglobulin E, and absolute eosinophil counts in asthma patients |
title_sort | relevance of skin prick test serum total immunoglobulin e and absolute eosinophil counts in asthma patients |
topic | asthma cockroach skin prick test spirometry total immunoglobulin e |
url | http://www.ijaai.in/article.asp?issn=0972-6691;year=2022;volume=36;issue=1;spage=54;epage=59;aulast=Kumar |
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