Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis
Kikuchi-Fujimoto disease (KFD, necrotizing lymphadenitis) is defined pathologically by enlarged lymph nodes with characteristic microscopic findings and nearly always follows a self-limiting benign clinical course. We report a case of KFD in a 47 year-old man who presented with weight loss, fever, e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Human Pathology: Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214330015300407 |
| _version_ | 1811337081883983872 |
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| author | Corey Costantino Peter Stenzel |
| author_facet | Corey Costantino Peter Stenzel |
| author_sort | Corey Costantino |
| collection | DOAJ |
| description | Kikuchi-Fujimoto disease (KFD, necrotizing lymphadenitis) is defined pathologically by enlarged lymph nodes with characteristic microscopic findings and nearly always follows a self-limiting benign clinical course. We report a case of KFD in a 47 year-old man who presented with weight loss, fever, enlarged lymph nodes and elevated serum levels of aminotransferases and bilirubin. He developed hemophagocytic lymphohistiocytosis (HLH) and died in liver failure. At autopsy, histologic findings characteristic of KFD (necrosis, histiocyte accumulation, karyorrhectic debris, absence of neutrophils) were present in lymph nodes, spleen, and liver. Similar changes were recognized upon review of a liver biopsy taken 4 weeks before death. This case demonstrates hepatic manifestations of KFD. |
| first_indexed | 2024-04-13T17:48:53Z |
| format | Article |
| id | doaj.art-6dd01a0a1b934fdabb48e1f2b611ad12 |
| institution | Directory Open Access Journal |
| issn | 2214-3300 |
| language | English |
| last_indexed | 2024-04-13T17:48:53Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology: Case Reports |
| spelling | doaj.art-6dd01a0a1b934fdabb48e1f2b611ad122022-12-22T02:36:48ZengElsevierHuman Pathology: Case Reports2214-33002016-09-015C1510.1016/j.ehpc.2015.09.002Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosisCorey CostantinoPeter StenzelKikuchi-Fujimoto disease (KFD, necrotizing lymphadenitis) is defined pathologically by enlarged lymph nodes with characteristic microscopic findings and nearly always follows a self-limiting benign clinical course. We report a case of KFD in a 47 year-old man who presented with weight loss, fever, enlarged lymph nodes and elevated serum levels of aminotransferases and bilirubin. He developed hemophagocytic lymphohistiocytosis (HLH) and died in liver failure. At autopsy, histologic findings characteristic of KFD (necrosis, histiocyte accumulation, karyorrhectic debris, absence of neutrophils) were present in lymph nodes, spleen, and liver. Similar changes were recognized upon review of a liver biopsy taken 4 weeks before death. This case demonstrates hepatic manifestations of KFD.http://www.sciencedirect.com/science/article/pii/S2214330015300407 |
| spellingShingle | Corey Costantino Peter Stenzel Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis Human Pathology: Case Reports |
| title | Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis |
| title_full | Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis |
| title_fullStr | Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis |
| title_full_unstemmed | Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis |
| title_short | Kikuchi-Fujimoto disease with lymph node, spleen, and liver involvement: Report of a fatal adult case with hemophagocytic lymphohistiocytosis |
| title_sort | kikuchi fujimoto disease with lymph node spleen and liver involvement report of a fatal adult case with hemophagocytic lymphohistiocytosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214330015300407 |
| work_keys_str_mv | AT coreycostantino kikuchifujimotodiseasewithlymphnodespleenandliverinvolvementreportofafataladultcasewithhemophagocyticlymphohistiocytosis AT peterstenzel kikuchifujimotodiseasewithlymphnodespleenandliverinvolvementreportofafataladultcasewithhemophagocyticlymphohistiocytosis |