Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity
Zinc oxide nanoparticles (ZnO NPs) are establishing themselves as an important class of nanomaterials due to their exceptional physicochemical properties and wide range of applications. Due to their affordability, lack of toxicity, and strong biocompatibility, ZnO NPs find extensive use in the field...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364723004196 |
| _version_ | 1797454352294608896 |
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| author | Ibrahim Ahmed Shaikh Bhagya Turakani Mater H. Mahnashi Ali S. Alqahtani Sumyya H. Hariri Mohammed M. Ghoneim Hasnaa Ali Ebrahim Mohamed El-Sherbiny Basheerahmed Abdulaziz Mannasaheb Uday M. Muddapur Gulrana Khuwaja Aejaz Abdullatif Khan Salah Eldeen Dafalla Touseef Begum S.M. Shakeel Iqubal |
| author_facet | Ibrahim Ahmed Shaikh Bhagya Turakani Mater H. Mahnashi Ali S. Alqahtani Sumyya H. Hariri Mohammed M. Ghoneim Hasnaa Ali Ebrahim Mohamed El-Sherbiny Basheerahmed Abdulaziz Mannasaheb Uday M. Muddapur Gulrana Khuwaja Aejaz Abdullatif Khan Salah Eldeen Dafalla Touseef Begum S.M. Shakeel Iqubal |
| author_sort | Ibrahim Ahmed Shaikh |
| collection | DOAJ |
| description | Zinc oxide nanoparticles (ZnO NPs) are establishing themselves as an important class of nanomaterials due to their exceptional physicochemical properties and wide range of applications. Due to their affordability, lack of toxicity, and strong biocompatibility, ZnO NPs find extensive use in the field of biomedicine. ZnO NPs are promising in biomedicine, especially for their ability as anticancer and antimicrobial agents. The ecologically sustainable preparation of metallic NPs using different plant extracts is a viable alternative to more conventional synthesis methods. The present study investigates the effects of changing the physical conditions on ZnO NPs synthesis from Bixa orellana (B. orellana) extract using the precipitation method. Confirmation and characterization of the ZnO NPs were achieved by analytical techniques. EDS results verified that highly pure ZnO NPs were synthesized. X-ray diffraction analysis verified the crystal nature of the synthesized NPs and their crystalline particle size of 82.66 nm. The XRD graphs strongly indicate the formation of wurtzite ZnO due to the presence of the (100), (002), and (101) planes. The antibacterial activity was assessed through the utilization of agar disc diffusion. The findings revealed that ZnO NPs exhibited significant efficacy in inhibiting the growth of both Gram-positive and Gram-negative bacteria. The zone of inhibition with the greatest diameter (22 mm) was reported for the bacterial strain B. cereus. The present investigation provides evidence that B. orellana leaves extract is capable of producing ZnO NPs, which play a crucial role in its antibacterial action. Additional investigation is necessary to validate the role of diverse phytochemicals in the synthesis of ZnO NPs and their applications in diverse fields such as agriculture, cosmetics, food, and healthcare. |
| first_indexed | 2024-03-09T15:36:02Z |
| format | Article |
| id | doaj.art-6dd2afc0f183421ea9b2ead9b2676fd8 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-03-09T15:36:02Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-6dd2afc0f183421ea9b2ead9b2676fd82023-11-26T05:11:55ZengElsevierJournal of King Saud University: Science1018-36472023-12-013511102957Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activityIbrahim Ahmed Shaikh0Bhagya Turakani1Mater H. Mahnashi2Ali S. Alqahtani3Sumyya H. Hariri4Mohammed M. Ghoneim5Hasnaa Ali Ebrahim6Mohamed El-Sherbiny7Basheerahmed Abdulaziz Mannasaheb8Uday M. Muddapur9Gulrana Khuwaja10Aejaz Abdullatif Khan11Salah Eldeen Dafalla12Touseef Begum13S.M. Shakeel Iqubal14Department of Pharmacology, College of Pharmacy, Najran University, Najran 66462, Saudi ArabiaDepartment of Biotechnology, KLE Technological University, Hubballi, Karnataka 580031, IndiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 66462, Saudi ArabiaDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Khalid University, Saudi ArabiaDepartment of Microbiology, College of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, EgyptDepartment of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia; Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura 35516, EgyptDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Biotechnology, KLE Technological University, Hubballi, Karnataka 580031, India; Corresponding authors at: Department of General Science, Ibn Sina National College for Medical Studies, Al Mahajar Street: 31906, Jeddah 21418, Saudi Arabia (S.M. Shakeel Iqubal), KLE Technological University, Hubballi, Karnataka 580031, India (U.M. Muddapur).Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaDepartment of General Science, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi ArabiaDepartment of Human Anatomy, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi ArabiaDepartment of Pharmaceutical Sciences, Ibn Sina National College for Medical Studies, Jeddah, Saudi ArabiaDepartment of General Science, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi Arabia; Corresponding authors at: Department of General Science, Ibn Sina National College for Medical Studies, Al Mahajar Street: 31906, Jeddah 21418, Saudi Arabia (S.M. Shakeel Iqubal), KLE Technological University, Hubballi, Karnataka 580031, India (U.M. Muddapur).Zinc oxide nanoparticles (ZnO NPs) are establishing themselves as an important class of nanomaterials due to their exceptional physicochemical properties and wide range of applications. Due to their affordability, lack of toxicity, and strong biocompatibility, ZnO NPs find extensive use in the field of biomedicine. ZnO NPs are promising in biomedicine, especially for their ability as anticancer and antimicrobial agents. The ecologically sustainable preparation of metallic NPs using different plant extracts is a viable alternative to more conventional synthesis methods. The present study investigates the effects of changing the physical conditions on ZnO NPs synthesis from Bixa orellana (B. orellana) extract using the precipitation method. Confirmation and characterization of the ZnO NPs were achieved by analytical techniques. EDS results verified that highly pure ZnO NPs were synthesized. X-ray diffraction analysis verified the crystal nature of the synthesized NPs and their crystalline particle size of 82.66 nm. The XRD graphs strongly indicate the formation of wurtzite ZnO due to the presence of the (100), (002), and (101) planes. The antibacterial activity was assessed through the utilization of agar disc diffusion. The findings revealed that ZnO NPs exhibited significant efficacy in inhibiting the growth of both Gram-positive and Gram-negative bacteria. The zone of inhibition with the greatest diameter (22 mm) was reported for the bacterial strain B. cereus. The present investigation provides evidence that B. orellana leaves extract is capable of producing ZnO NPs, which play a crucial role in its antibacterial action. Additional investigation is necessary to validate the role of diverse phytochemicals in the synthesis of ZnO NPs and their applications in diverse fields such as agriculture, cosmetics, food, and healthcare.http://www.sciencedirect.com/science/article/pii/S1018364723004196AntimicrobialBixa orellanaZinc oxide nanoparticlesCharacterizationGreen synthesis |
| spellingShingle | Ibrahim Ahmed Shaikh Bhagya Turakani Mater H. Mahnashi Ali S. Alqahtani Sumyya H. Hariri Mohammed M. Ghoneim Hasnaa Ali Ebrahim Mohamed El-Sherbiny Basheerahmed Abdulaziz Mannasaheb Uday M. Muddapur Gulrana Khuwaja Aejaz Abdullatif Khan Salah Eldeen Dafalla Touseef Begum S.M. Shakeel Iqubal Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity Journal of King Saud University: Science Antimicrobial Bixa orellana Zinc oxide nanoparticles Characterization Green synthesis |
| title | Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity |
| title_full | Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity |
| title_fullStr | Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity |
| title_full_unstemmed | Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity |
| title_short | Environmentally friendly production, characterization, and evaluation of ZnO NPs from Bixa orellana leaf extract and assessment of its antimicrobial activity |
| title_sort | environmentally friendly production characterization and evaluation of zno nps from bixa orellana leaf extract and assessment of its antimicrobial activity |
| topic | Antimicrobial Bixa orellana Zinc oxide nanoparticles Characterization Green synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S1018364723004196 |
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