Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents
Thiazolidinediones are well known for causing reduction in blood glucose levels. A number of thiazolidinediones have been approved for clinical use in diabetes. Present research work is based on the synthesis of thiazolidinedione derivatives that were designed previously using 2D QSAR for antidiabet...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-09-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610312001615 |
| _version_ | 1818672843937808384 |
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| author | Prasanna A. Datar Sainath B. Aher |
| author_facet | Prasanna A. Datar Sainath B. Aher |
| author_sort | Prasanna A. Datar |
| collection | DOAJ |
| description | Thiazolidinediones are well known for causing reduction in blood glucose levels. A number of thiazolidinediones have been approved for clinical use in diabetes. Present research work is based on the synthesis of thiazolidinedione derivatives that were designed previously using 2D QSAR for antidiabetic activity. Thiazolidine-2,4-diones derivatives having carboxylic ester appendages at N-3 and 5-substituted benzylidene were studied and the syntheses of only four derivatives were performed that were predicted to have promising antidiabetic activities. Their effect on hypoglycemic activity was performed using a sucrose loaded model. Compounds 5a and 5b were found to have prominent activities at 100 mg/kg by oral route administration. |
| first_indexed | 2024-12-17T07:46:21Z |
| format | Article |
| id | doaj.art-6dd2fbb15a8b4ca1bccdb52c99a4853f |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-17T07:46:21Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-6dd2fbb15a8b4ca1bccdb52c99a4853f2022-12-21T21:58:00ZengElsevierJournal of Saudi Chemical Society1319-61032016-09-0120S1S196S20110.1016/j.jscs.2012.10.010Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agentsPrasanna A. DatarSainath B. AherThiazolidinediones are well known for causing reduction in blood glucose levels. A number of thiazolidinediones have been approved for clinical use in diabetes. Present research work is based on the synthesis of thiazolidinedione derivatives that were designed previously using 2D QSAR for antidiabetic activity. Thiazolidine-2,4-diones derivatives having carboxylic ester appendages at N-3 and 5-substituted benzylidene were studied and the syntheses of only four derivatives were performed that were predicted to have promising antidiabetic activities. Their effect on hypoglycemic activity was performed using a sucrose loaded model. Compounds 5a and 5b were found to have prominent activities at 100 mg/kg by oral route administration.http://www.sciencedirect.com/science/article/pii/S13196103120016152D QSARMLRHypoglycemic activityThiazolidinedionesDiabetesSucrose loaded model (SLM) |
| spellingShingle | Prasanna A. Datar Sainath B. Aher Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents Journal of Saudi Chemical Society 2D QSAR MLR Hypoglycemic activity Thiazolidinediones Diabetes Sucrose loaded model (SLM) |
| title | Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents |
| title_full | Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents |
| title_fullStr | Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents |
| title_full_unstemmed | Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents |
| title_short | Design and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agents |
| title_sort | design and synthesis of novel thiazolidine 2 4 diones as hypoglycemic agents |
| topic | 2D QSAR MLR Hypoglycemic activity Thiazolidinediones Diabetes Sucrose loaded model (SLM) |
| url | http://www.sciencedirect.com/science/article/pii/S1319610312001615 |
| work_keys_str_mv | AT prasannaadatar designandsynthesisofnovelthiazolidine24dionesashypoglycemicagents AT sainathbaher designandsynthesisofnovelthiazolidine24dionesashypoglycemicagents |