The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1

The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1

PD-L1 has been characterized as an inhibitory immune checkpoint, leading to the suppression of potential anti-tumor immune activities in many cancer types. In view of the relatively limited efficacy of immune checkpoint blockades against PD-L1 in breast cancer, our recent study addressed the possibi...

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Bibliographic Details
Main Authors: Nofar Erlichman, Tsipi Meshel, Tamir Baram, Alaa Abu Raiya, Tamar Horvitz, Hagar Ben-Yaakov, Adit Ben-Baruch
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
Breast cancer
N-linked glycosylation
PD-1
PD-L1
STAT1
STAT3
Online Access:https://www.mdpi.com/2073-4409/12/19/2338

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