Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM

Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM

Abstract Renal fibrosis is a common pathological feature and outcome of almost all chronic kidney diseases, and it is characterized by metabolic reprogramming toward aerobic glycolysis. Mesenchymal stem cell-derived exosomes (MSC-Exos) have been proposed as a promising therapeutic approach for renal...

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Bibliographic Details
Main Authors: Shihao Xu, Yin Celeste Cheuk, Yichen Jia, Tian Chen, Juntao Chen, Yongsheng Luo, Yirui Cao, Jingjing Guo, Lijun Dong, Yi Zhang, Yi Shi, Ruiming Rong
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05305-7

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