Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522003276 |
| _version_ | 1811208370096439296 |
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| author | Zhicheng Xie Lin Li Yihao Guo Mi Zhang Taiwen Chen Yongpeng Li Xin Li Xi Zhu Yu Zhang Liguang Lou Youhong Hu |
| author_facet | Zhicheng Xie Lin Li Yihao Guo Mi Zhang Taiwen Chen Yongpeng Li Xin Li Xi Zhu Yu Zhang Liguang Lou Youhong Hu |
| author_sort | Zhicheng Xie |
| collection | DOAJ |
| first_indexed | 2024-04-12T04:20:00Z |
| format | Article |
| id | doaj.art-6dd6eae4e04d466d9bdb255d98d97132 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-12T04:20:00Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-6dd6eae4e04d466d9bdb255d98d971322022-12-22T03:48:15ZengElsevierActa Pharmaceutica Sinica B2211-38352022-10-01121040044007Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumorsZhicheng Xie0Lin Li1Yihao Guo2Mi Zhang3Taiwen Chen4Yongpeng Li5Xin Li6Xi Zhu7Yu Zhang8Liguang Lou9Youhong Hu10State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; Corresponding authors. Tel.: +86 21 50806600.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Corresponding authors. Tel.: +86 21 50806600.http://www.sciencedirect.com/science/article/pii/S2211383522003276KITD816VcellsMutationDrug resistanceGastrointestinal stromal tumors |
| spellingShingle | Zhicheng Xie Lin Li Yihao Guo Mi Zhang Taiwen Chen Yongpeng Li Xin Li Xi Zhu Yu Zhang Liguang Lou Youhong Hu Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors Acta Pharmaceutica Sinica B KITD816Vcells Mutation Drug resistance Gastrointestinal stromal tumors |
| title | Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors |
| title_full | Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors |
| title_fullStr | Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors |
| title_full_unstemmed | Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors |
| title_short | Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors |
| title_sort | discovery of novel heteroaryl alkynes for highly potent kitd816v cells inhibition to treat gastrointestinal stromal tumors |
| topic | KITD816Vcells Mutation Drug resistance Gastrointestinal stromal tumors |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522003276 |
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