Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
Introduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of the anesthesiologist. This study was performed to compare th...
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Society of Surgeons of Nepal
2017-04-01
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| Series: | Journal of Society of Surgeons of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JSSN/article/view/17144 |
| _version_ | 1819237476415307776 |
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| author | Ram Bhakta Koju Y Dongol |
| author_facet | Ram Bhakta Koju Y Dongol |
| author_sort | Ram Bhakta Koju |
| collection | DOAJ |
| description | Introduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of the anesthesiologist. This study was performed to compare the safety and effectiveness of lidocaine and esmolol in comparison to placebo-control group, in modifying the hemodynamic response to laryngoscopy and intubation.
Methods: After approval of the study protocol by the institutional review board (IRB), written informed consent was obtained from each patient. It was a randomized placebo-controlled, double-blinded study. 75 patients of American Society of Anesthesiologists physical status I and II, scheduled for general surgery under GA, aged between 20-60 years were randomly allocated into three groups: placebo control group (n=25), lidocaine group (n=25) and esmolol group (n=25). Placebo group received 12 ml normal saline, lidocaine group received 1.5mg/kg lidocaine (total volume 12 ml) and esmolol group received 1.4mg/kg esmolol (total volume 12ml).
Results: Following laryngoscopy and intubation, the increase in systolic blood pressure, diastolic blood pressure and heart rate were significantly lower (p < 0.05) in esmolol group compared to the lidocaine and placebo group but there was no statistical significance (p > 0.05) between control and lidocaine group.
Conclusion: Esmolol 1.4 mg/kg IV was significantly more effective in controlling the hemodynamic response following laryngoscopy and intubation in comparison to lidocaine 1.5 mg/kg.
Journal of Society of Surgeons of Nepal
Vol. 17, No. 2, 2014, Page: 23-30 |
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| format | Article |
| id | doaj.art-6dd85c63e3d4450981089c77be08f5c4 |
| institution | Directory Open Access Journal |
| issn | 1815-3984 2392-4772 |
| language | English |
| last_indexed | 2024-12-23T13:20:56Z |
| publishDate | 2017-04-01 |
| publisher | Society of Surgeons of Nepal |
| record_format | Article |
| series | Journal of Society of Surgeons of Nepal |
| spelling | doaj.art-6dd85c63e3d4450981089c77be08f5c42022-12-21T17:45:28ZengSociety of Surgeons of NepalJournal of Society of Surgeons of Nepal1815-39842392-47722017-04-0117210.3126/jssn.v17i2.17144Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubationRam Bhakta Koju0Y Dongol1KIST Medical College and Teaching Hospital, LalitpurKIST Medical College and Teaching Hospital, LalitpurIntroduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of the anesthesiologist. This study was performed to compare the safety and effectiveness of lidocaine and esmolol in comparison to placebo-control group, in modifying the hemodynamic response to laryngoscopy and intubation. Methods: After approval of the study protocol by the institutional review board (IRB), written informed consent was obtained from each patient. It was a randomized placebo-controlled, double-blinded study. 75 patients of American Society of Anesthesiologists physical status I and II, scheduled for general surgery under GA, aged between 20-60 years were randomly allocated into three groups: placebo control group (n=25), lidocaine group (n=25) and esmolol group (n=25). Placebo group received 12 ml normal saline, lidocaine group received 1.5mg/kg lidocaine (total volume 12 ml) and esmolol group received 1.4mg/kg esmolol (total volume 12ml). Results: Following laryngoscopy and intubation, the increase in systolic blood pressure, diastolic blood pressure and heart rate were significantly lower (p < 0.05) in esmolol group compared to the lidocaine and placebo group but there was no statistical significance (p > 0.05) between control and lidocaine group. Conclusion: Esmolol 1.4 mg/kg IV was significantly more effective in controlling the hemodynamic response following laryngoscopy and intubation in comparison to lidocaine 1.5 mg/kg. Journal of Society of Surgeons of Nepal Vol. 17, No. 2, 2014, Page: 23-30https://www.nepjol.info/index.php/JSSN/article/view/17144Cardiovascular responseEsmololHemodynamicsIntubationLaryngoscopyLidocaine |
| spellingShingle | Ram Bhakta Koju Y Dongol Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation Journal of Society of Surgeons of Nepal Cardiovascular response Esmolol Hemodynamics Intubation Laryngoscopy Lidocaine |
| title | Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation |
| title_full | Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation |
| title_fullStr | Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation |
| title_full_unstemmed | Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation |
| title_short | Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation |
| title_sort | comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation |
| topic | Cardiovascular response Esmolol Hemodynamics Intubation Laryngoscopy Lidocaine |
| url | https://www.nepjol.info/index.php/JSSN/article/view/17144 |
| work_keys_str_mv | AT rambhaktakoju comparativeeffectsoflidocaineandesmololinattenuatingthehemodynamicresponsetolaryngoscopyandintubation AT ydongol comparativeeffectsoflidocaineandesmololinattenuatingthehemodynamicresponsetolaryngoscopyandintubation |