In search of a ‘pan-European value set’; application for EQ-5D-3L
Abstract Objectives Country-specific value sets for the EQ-5D are available which reflect preferences for health states elicited from the general population. This allows the transformation of responses on EQ-5D to health state utility values. Only twelve European countries possess country-specific v...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Medical Research Methodology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12874-022-01830-3 |
| _version_ | 1797952485685460992 |
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| author | Ayesha Sajjad Matthijs M. Versteegh Irene Santi Jan Busschbach Judit Simon Leona Hakkaart-van Roijen |
| author_facet | Ayesha Sajjad Matthijs M. Versteegh Irene Santi Jan Busschbach Judit Simon Leona Hakkaart-van Roijen |
| author_sort | Ayesha Sajjad |
| collection | DOAJ |
| description | Abstract Objectives Country-specific value sets for the EQ-5D are available which reflect preferences for health states elicited from the general population. This allows the transformation of responses on EQ-5D to health state utility values. Only twelve European countries possess country-specific value sets and no value set reflecting the preferences of Europe exists. We aim to estimate a ‘pan-European’ value set for the EQ-5D-3L, reflecting the preferences for health states of the European population that could help to evaluate health care from the perspective of the European decision-maker. Methods We systematically assessed and compared the methodologies of available EQ-5D-3L time trade-off (TTO) value sets from twelve European countries: Denmark, France, Germany, Hungary, Italy, Netherlands, Poland, Portugal, Romania, Slovenia, Spain and UK. Using their published coefficients, a dataset with utility values for all 243 health states was simulated. Different modelling techniques and model specifications including interaction terms were tested. Model selection was based on goodness-of-fit criteria. We also explored results with application of population size weights. Results Methodological, procedural and analytical characteristics of the included EQ-5D-3L valuation studies were quite comparable. An OLS based model was the preferred model to represent European preferences. Weighting with population size made little difference. Conclusions EQ-5D-3L valuation studies were considered of sufficient comparability to form the basis for a new ‘pan-European’ value set. The method used allows for an easy update when new national value sets become available. |
| first_indexed | 2024-04-10T22:47:06Z |
| format | Article |
| id | doaj.art-6dd8accbef3a4a45abed1d231449a393 |
| institution | Directory Open Access Journal |
| issn | 1471-2288 |
| language | English |
| last_indexed | 2024-04-10T22:47:06Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Research Methodology |
| spelling | doaj.art-6dd8accbef3a4a45abed1d231449a3932023-01-15T12:15:04ZengBMCBMC Medical Research Methodology1471-22882023-01-012311910.1186/s12874-022-01830-3In search of a ‘pan-European value set’; application for EQ-5D-3LAyesha Sajjad0Matthijs M. Versteegh1Irene Santi2Jan Busschbach3Judit Simon4Leona Hakkaart-van Roijen5Erasmus School of Health Policy and Management, Erasmus University RotterdamInstitute for Medical Technology Assessment (iMTA), Erasmus University RotterdamInstitute for Medical Technology Assessment (iMTA), Erasmus University RotterdamSection of Medical Psychology and Psychotherapy, Erasmus MCDepartment of Health Economics, Center for Public Health, Medical University of ViennaErasmus School of Health Policy and Management, Erasmus University RotterdamAbstract Objectives Country-specific value sets for the EQ-5D are available which reflect preferences for health states elicited from the general population. This allows the transformation of responses on EQ-5D to health state utility values. Only twelve European countries possess country-specific value sets and no value set reflecting the preferences of Europe exists. We aim to estimate a ‘pan-European’ value set for the EQ-5D-3L, reflecting the preferences for health states of the European population that could help to evaluate health care from the perspective of the European decision-maker. Methods We systematically assessed and compared the methodologies of available EQ-5D-3L time trade-off (TTO) value sets from twelve European countries: Denmark, France, Germany, Hungary, Italy, Netherlands, Poland, Portugal, Romania, Slovenia, Spain and UK. Using their published coefficients, a dataset with utility values for all 243 health states was simulated. Different modelling techniques and model specifications including interaction terms were tested. Model selection was based on goodness-of-fit criteria. We also explored results with application of population size weights. Results Methodological, procedural and analytical characteristics of the included EQ-5D-3L valuation studies were quite comparable. An OLS based model was the preferred model to represent European preferences. Weighting with population size made little difference. Conclusions EQ-5D-3L valuation studies were considered of sufficient comparability to form the basis for a new ‘pan-European’ value set. The method used allows for an easy update when new national value sets become available.https://doi.org/10.1186/s12874-022-01830-3UtilitiesEQ-5D-3LValue setTime trade-offEurope |
| spellingShingle | Ayesha Sajjad Matthijs M. Versteegh Irene Santi Jan Busschbach Judit Simon Leona Hakkaart-van Roijen In search of a ‘pan-European value set’; application for EQ-5D-3L BMC Medical Research Methodology Utilities EQ-5D-3L Value set Time trade-off Europe |
| title | In search of a ‘pan-European value set’; application for EQ-5D-3L |
| title_full | In search of a ‘pan-European value set’; application for EQ-5D-3L |
| title_fullStr | In search of a ‘pan-European value set’; application for EQ-5D-3L |
| title_full_unstemmed | In search of a ‘pan-European value set’; application for EQ-5D-3L |
| title_short | In search of a ‘pan-European value set’; application for EQ-5D-3L |
| title_sort | in search of a pan european value set application for eq 5d 3l |
| topic | Utilities EQ-5D-3L Value set Time trade-off Europe |
| url | https://doi.org/10.1186/s12874-022-01830-3 |
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