PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES
Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease, autoimmune disorders, cardiovascular calcification etc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2018-06-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1556 |
| _version_ | 1797197949281763328 |
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| author | A. S. Golovkin I. A. Asadullina I. V. Kudryavtsev |
| author_facet | A. S. Golovkin I. A. Asadullina I. V. Kudryavtsev |
| author_sort | A. S. Golovkin |
| collection | DOAJ |
| description | Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease, autoimmune disorders, cardiovascular calcification etc. It has been shown that the purinergic system mediates fine tuning of the immune cell populations, like as cytokine and chemokine secretion, elimination of intracellular pathogens and mechanisms of programmed cell death. Novel approaches to therapy and disease prevention are based on studies of appropriate developmental mechanisms, including role of purinergic system in their regulation. This review contains analysis of recent achievements elucidating the role of purinergic regulation in pathogenesis of basic pathological conditions and diseases, as well as trends in development of new therapeutic approaches based on present knowledge. |
| first_indexed | 2024-03-08T05:48:46Z |
| format | Article |
| id | doaj.art-6dd90a338bfb4e17a9b932c85e24b151 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:05Z |
| publishDate | 2018-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-6dd90a338bfb4e17a9b932c85e24b1512024-04-22T13:07:43ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2018-06-0120446347610.15789/1563-0625-2018-4-463-4761023PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSESA. S. Golovkin0I. A. Asadullina1I. V. Kudryavtsev2V.A. Almazov National Medical Research CentreInstitute of Experimental MedicineInstitute of Experimental Medicine; First St. Petersburg State I.P. Pavlov Medical UniversityPurinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease, autoimmune disorders, cardiovascular calcification etc. It has been shown that the purinergic system mediates fine tuning of the immune cell populations, like as cytokine and chemokine secretion, elimination of intracellular pathogens and mechanisms of programmed cell death. Novel approaches to therapy and disease prevention are based on studies of appropriate developmental mechanisms, including role of purinergic system in their regulation. This review contains analysis of recent achievements elucidating the role of purinergic regulation in pathogenesis of basic pathological conditions and diseases, as well as trends in development of new therapeutic approaches based on present knowledge.https://www.mimmun.ru/mimmun/article/view/1556purinergic regulationcd39cd73atpadenosine |
| spellingShingle | A. S. Golovkin I. A. Asadullina I. V. Kudryavtsev PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES Медицинская иммунология purinergic regulation cd39 cd73 atp adenosine |
| title | PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES |
| title_full | PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES |
| title_fullStr | PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES |
| title_full_unstemmed | PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES |
| title_short | PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES |
| title_sort | purinergic regulation of basic physiological and pathological processes |
| topic | purinergic regulation cd39 cd73 atp adenosine |
| url | https://www.mimmun.ru/mimmun/article/view/1556 |
| work_keys_str_mv | AT asgolovkin purinergicregulationofbasicphysiologicalandpathologicalprocesses AT iaasadullina purinergicregulationofbasicphysiologicalandpathologicalprocesses AT ivkudryavtsev purinergicregulationofbasicphysiologicalandpathologicalprocesses |