Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats
OBJECTIVE: The objective of this study was to examine the separate and combined effects of tobacco and biomass smoke exposure on pulmonary histopathology in rats. INTRODUCTION: In addition to smoking, indoor pollution in developing countries contributes to the development of respiratory diseases. ME...
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| Format: | Article |
| Language: | English |
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Elsevier España
2011-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000600027 |
| _version_ | 1811330650302578688 |
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| author | Omer Tamer Dogan Sahande Elagoz Sefa Levent Ozsahin Kursat Epozturk Ersin Tuncer Ibrahim Akkurt |
| author_facet | Omer Tamer Dogan Sahande Elagoz Sefa Levent Ozsahin Kursat Epozturk Ersin Tuncer Ibrahim Akkurt |
| author_sort | Omer Tamer Dogan |
| collection | DOAJ |
| description | OBJECTIVE: The objective of this study was to examine the separate and combined effects of tobacco and biomass smoke exposure on pulmonary histopathology in rats. INTRODUCTION: In addition to smoking, indoor pollution in developing countries contributes to the development of respiratory diseases. METHODS: Twenty-eight adult rats were divided into four groups as follows: control group (Group I, no exposure to tobacco or biomass smoke), exposed to tobacco smoke (Group II), exposed to biomass smoke (Group III), and combined exposure to tobacco and biomass smoke (Group IV). After six months the rats in all four groups were sacrificed. Lung tissue samples were examined under light microscopy. The severity of pathological changes was scored. RESULTS: Group II differed from Group I in all histopathological alterations except intraparenchymal vascular thrombosis. There was no statistically significant difference in histopathological changes between the subjects exposed exclusively to tobacco smoke (Group II) and those with combined exposure to tobacco and biomass smoke (Group IV). The histopathological changes observed in Group IV were found to be more severe than those in subjects exposed exclusively to biomass smoke (Group III). DISCUSSION: Chronic exposure to tobacco and biomass smoke caused an increase in severity and types of lung injury. CONCLUSION: Exposure to cigarette smoke caused serious damage to the respiratory system, particularly with concomitant exposure to biomass smoke. |
| first_indexed | 2024-04-13T16:06:52Z |
| format | Article |
| id | doaj.art-6dd91db866c54b43a7bb058419a51c73 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T16:06:52Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-6dd91db866c54b43a7bb058419a51c732022-12-22T02:40:22ZengElsevier EspañaClinics1807-59321980-53222011-01-016661081108710.1590/S1807-59322011000600027Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in ratsOmer Tamer DoganSahande ElagozSefa Levent OzsahinKursat EpozturkErsin TuncerIbrahim AkkurtOBJECTIVE: The objective of this study was to examine the separate and combined effects of tobacco and biomass smoke exposure on pulmonary histopathology in rats. INTRODUCTION: In addition to smoking, indoor pollution in developing countries contributes to the development of respiratory diseases. METHODS: Twenty-eight adult rats were divided into four groups as follows: control group (Group I, no exposure to tobacco or biomass smoke), exposed to tobacco smoke (Group II), exposed to biomass smoke (Group III), and combined exposure to tobacco and biomass smoke (Group IV). After six months the rats in all four groups were sacrificed. Lung tissue samples were examined under light microscopy. The severity of pathological changes was scored. RESULTS: Group II differed from Group I in all histopathological alterations except intraparenchymal vascular thrombosis. There was no statistically significant difference in histopathological changes between the subjects exposed exclusively to tobacco smoke (Group II) and those with combined exposure to tobacco and biomass smoke (Group IV). The histopathological changes observed in Group IV were found to be more severe than those in subjects exposed exclusively to biomass smoke (Group III). DISCUSSION: Chronic exposure to tobacco and biomass smoke caused an increase in severity and types of lung injury. CONCLUSION: Exposure to cigarette smoke caused serious damage to the respiratory system, particularly with concomitant exposure to biomass smoke.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000600027Inhalation ToxicologyLung PathologyPulmonary DiseaseRatsSmoke |
| spellingShingle | Omer Tamer Dogan Sahande Elagoz Sefa Levent Ozsahin Kursat Epozturk Ersin Tuncer Ibrahim Akkurt Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats Clinics Inhalation Toxicology Lung Pathology Pulmonary Disease Rats Smoke |
| title | Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats |
| title_full | Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats |
| title_fullStr | Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats |
| title_full_unstemmed | Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats |
| title_short | Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats |
| title_sort | pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats |
| topic | Inhalation Toxicology Lung Pathology Pulmonary Disease Rats Smoke |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000600027 |
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