Differential protease content of mast cells and the processing of IL-33 in Alternaria alternata induced allergic airway inflammation in mice

Differential protease content of mast cells and the processing of IL-33 in Alternaria alternata induced allergic airway inflammation in mice

BackgroundRecent in vitro studies strongly implicated mast cell-derived proteases as regulators of IL-33 activity by enzymatic cleavage in its central domain. A better understanding of the role of mast cell proteases on IL-33 activity in vivo is needed. We aimed to compare the expression of mast cel...

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Bibliographic Details
Main Authors: Olga Krysko, Darya Korsakova, Andrea Teufelberger, Amse De Meyer, Jill Steels, Natalie De Ruyck, Judith van Ovost, Sharon Van Nevel, Gabriele Holtappels, Frauke Coppieters, Mikhail Ivanchenko, Harald Braun, Maria Vedunova, Dmitri V. Krysko, Claus Bachert
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
IL-33
mast cells
allergy
type 2 inflammation
protease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1040493/full

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