Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice
Mulberry leaf has potential in lipid-lowering. Here, we compared the chemical composition and lipid-lowering effects of different mulberry leaf-derived teas, and investigated their underlying gut microbiome-related mechanisms. The main components of mulberry leaf-derived tea were flavonoids, phenoli...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623005066 |
| _version_ | 1797435804232974336 |
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| author | Shi Zhong Yanan Yang Jinxi Huo Yuqing Sun Ning Ren Qinhua Lu Da Li Pengfei Zhan Weijie Wu Huizhi Chen Ben Niu Meiliang Pan Huanyan Ma Qinqiao Liu Qingsheng Li Chongming Wu Yougui Li |
| author_facet | Shi Zhong Yanan Yang Jinxi Huo Yuqing Sun Ning Ren Qinhua Lu Da Li Pengfei Zhan Weijie Wu Huizhi Chen Ben Niu Meiliang Pan Huanyan Ma Qinqiao Liu Qingsheng Li Chongming Wu Yougui Li |
| author_sort | Shi Zhong |
| collection | DOAJ |
| description | Mulberry leaf has potential in lipid-lowering. Here, we compared the chemical composition and lipid-lowering effects of different mulberry leaf-derived teas, and investigated their underlying gut microbiome-related mechanisms. The main components of mulberry leaf-derived tea were flavonoids, phenolic acids and alkaloids, with green tea (0.60% polyphenols, 3.35% polysaccharides, 0.20% DNJ) containing higher levels than black tea (0.40% polyphenols, 2.95% polysaccharides, 0.15% DNJ). Accordingly, the lipid-lowering efficacy of green tea was superior to that of black tea in high-fat (HFD)-induced hyperlipidemic mice. Black tea increased 2 genera and 130 metabolites, decreased 6 genera and 90 metabolites, while green tea increased 5 genera and 127 metabolites, decreased 15 genera and 64 metabolites. Correlation analysis showed that the alterations of gut microbiota and metabolic profiles caused by mulberry leaf tea were tightly associated with its lipid-lowering effect. Altogether, this study provided a promising functional food targeting gut microbiota for the management of lipid metabolism. |
| first_indexed | 2024-03-09T10:53:23Z |
| format | Article |
| id | doaj.art-6dda9e083bdb46fab79a78410aad0ced |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-09T10:53:23Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6dda9e083bdb46fab79a78410aad0ced2023-12-01T05:01:15ZengElsevierJournal of Functional Foods1756-46462023-12-01111105906Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in miceShi Zhong0Yanan Yang1Jinxi Huo2Yuqing Sun3Ning Ren4Qinhua Lu5Da Li6Pengfei Zhan7Weijie Wu8Huizhi Chen9Ben Niu10Meiliang Pan11Huanyan Ma12Qinqiao Liu13Qingsheng Li14Chongming Wu15Yougui Li16Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaHuzhou Agricultural Technology Extension Center, Huzhou Academy of Agricultural Sciences, Huzhou 313002, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, ChinaZhejiang Provincial Center for Agricultural Technology Extension, Zhejiang Provincial Department of Agriculture and Rural Affairs, Hangzhou 310020, ChinaZhejiang Provincial Center for Agricultural Technology Extension, Zhejiang Provincial Department of Agriculture and Rural Affairs, Hangzhou 310020, ChinaHuzhou Liuyin Biological Technology Co., LTD, Huzhou 313009, ChinaZhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; Corresponding authors at: Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (Yougui Li).School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Corresponding authors at: Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (Yougui Li).Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China; Corresponding authors at: Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China (Yougui Li).Mulberry leaf has potential in lipid-lowering. Here, we compared the chemical composition and lipid-lowering effects of different mulberry leaf-derived teas, and investigated their underlying gut microbiome-related mechanisms. The main components of mulberry leaf-derived tea were flavonoids, phenolic acids and alkaloids, with green tea (0.60% polyphenols, 3.35% polysaccharides, 0.20% DNJ) containing higher levels than black tea (0.40% polyphenols, 2.95% polysaccharides, 0.15% DNJ). Accordingly, the lipid-lowering efficacy of green tea was superior to that of black tea in high-fat (HFD)-induced hyperlipidemic mice. Black tea increased 2 genera and 130 metabolites, decreased 6 genera and 90 metabolites, while green tea increased 5 genera and 127 metabolites, decreased 15 genera and 64 metabolites. Correlation analysis showed that the alterations of gut microbiota and metabolic profiles caused by mulberry leaf tea were tightly associated with its lipid-lowering effect. Altogether, this study provided a promising functional food targeting gut microbiota for the management of lipid metabolism.http://www.sciencedirect.com/science/article/pii/S1756464623005066Mulberry leafMulberry teaLipid-loweringGut microbiotaMetabolomics |
| spellingShingle | Shi Zhong Yanan Yang Jinxi Huo Yuqing Sun Ning Ren Qinhua Lu Da Li Pengfei Zhan Weijie Wu Huizhi Chen Ben Niu Meiliang Pan Huanyan Ma Qinqiao Liu Qingsheng Li Chongming Wu Yougui Li Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice Journal of Functional Foods Mulberry leaf Mulberry tea Lipid-lowering Gut microbiota Metabolomics |
| title | Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice |
| title_full | Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice |
| title_fullStr | Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice |
| title_full_unstemmed | Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice |
| title_short | Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice |
| title_sort | dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea black mulberry leaf tea in mice |
| topic | Mulberry leaf Mulberry tea Lipid-lowering Gut microbiota Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623005066 |
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