Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19?
<i>Background and Aim</i>: Although vaccination practices continue at a fast pace around the world, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still threatens people’s lives. In this study, we aimed to determine the presence of SARS-CoV-2 in patients who do not have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/10/1460 |
| _version_ | 1797471580531458048 |
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| author | Kadir Gisi Sukru Gungor Murat Ispiroglu Bulent Kantarceken |
| author_facet | Kadir Gisi Sukru Gungor Murat Ispiroglu Bulent Kantarceken |
| author_sort | Kadir Gisi |
| collection | DOAJ |
| description | <i>Background and Aim</i>: Although vaccination practices continue at a fast pace around the world, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still threatens people’s lives. In this study, we aimed to determine the presence of SARS-CoV-2 in patients who do not have the typical symptoms of the novel coronavirus disease 2019 (COVID-19), but only present with dyspepsia, and to investigate the role of immature granulocytes in the early diagnosis of these patients. <i>Material and Methods</i>: Adult and pediatric patients suffering from dyspepsia were included in the study. The patients were divided into two groups, ‘‘positive’’ and ‘‘negative’’, based on their SARS-CoV-2 polymerase chain reaction test results. Immature granulocyte count (IG), immature granulocyte percentage (IG%), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) values were recorded. <i>Results:</i> A total of 238 patients, including 25 (10.5%) pediatric and 213 (89.5%) adult patients, were included in the study. A total of 2 (8%) pediatric patients and 17 (7.9%) adult patients tested positive for SARS-CoV-2. The IG, IG%, and CRP parameters were significantly higher in the SARS-CoV-2-positive patients compared to the SARS-CoV-2-negative patients. The optimal cut-off value predictive of COVID-19 infection was determined to be ≥0.650 (sensitivity: 52.6% and specificity: 95.5%, <i>p</i> = 0.001) for IG%. <i>Conclusions:</i> It should be noted that dyspepsia may also be a COVID-19 symptom. IG% values, which can be determined with a hemogram test, a cheap and easily accessible test, may be a warning in the early detection of patients who do not have the typical symptoms of COVID-19. |
| first_indexed | 2024-03-09T19:50:40Z |
| format | Article |
| id | doaj.art-6ddab1fa153643218b7911811f03e506 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T19:50:40Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-6ddab1fa153643218b7911811f03e5062023-11-24T01:11:34ZengMDPI AGMedicina1010-660X1648-91442022-10-015810146010.3390/medicina58101460Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19?Kadir Gisi0Sukru Gungor1Murat Ispiroglu2Bulent Kantarceken3Department of Gastroenterology, Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Pediatric Gastroenterology, Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Gastroenterology, Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Gastroenterology, Sutcu Imam University, Kahramanmaras 46050, Turkey<i>Background and Aim</i>: Although vaccination practices continue at a fast pace around the world, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still threatens people’s lives. In this study, we aimed to determine the presence of SARS-CoV-2 in patients who do not have the typical symptoms of the novel coronavirus disease 2019 (COVID-19), but only present with dyspepsia, and to investigate the role of immature granulocytes in the early diagnosis of these patients. <i>Material and Methods</i>: Adult and pediatric patients suffering from dyspepsia were included in the study. The patients were divided into two groups, ‘‘positive’’ and ‘‘negative’’, based on their SARS-CoV-2 polymerase chain reaction test results. Immature granulocyte count (IG), immature granulocyte percentage (IG%), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) values were recorded. <i>Results:</i> A total of 238 patients, including 25 (10.5%) pediatric and 213 (89.5%) adult patients, were included in the study. A total of 2 (8%) pediatric patients and 17 (7.9%) adult patients tested positive for SARS-CoV-2. The IG, IG%, and CRP parameters were significantly higher in the SARS-CoV-2-positive patients compared to the SARS-CoV-2-negative patients. The optimal cut-off value predictive of COVID-19 infection was determined to be ≥0.650 (sensitivity: 52.6% and specificity: 95.5%, <i>p</i> = 0.001) for IG%. <i>Conclusions:</i> It should be noted that dyspepsia may also be a COVID-19 symptom. IG% values, which can be determined with a hemogram test, a cheap and easily accessible test, may be a warning in the early detection of patients who do not have the typical symptoms of COVID-19.https://www.mdpi.com/1648-9144/58/10/1460COVID-19digestive symptomdyspepsiaimmature granulocyte |
| spellingShingle | Kadir Gisi Sukru Gungor Murat Ispiroglu Bulent Kantarceken Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19? Medicina COVID-19 digestive symptom dyspepsia immature granulocyte |
| title | Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19? |
| title_full | Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19? |
| title_fullStr | Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19? |
| title_full_unstemmed | Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19? |
| title_short | Could an Increased Percentage of Immature Granulocytes Accompanying Dyspepsia Predict COVID-19? |
| title_sort | could an increased percentage of immature granulocytes accompanying dyspepsia predict covid 19 |
| topic | COVID-19 digestive symptom dyspepsia immature granulocyte |
| url | https://www.mdpi.com/1648-9144/58/10/1460 |
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